Vitamin D, Folate, and Cobalamin Serum Concentrations Are Related to Brain Volume and White Matter Integrity in Urban Adults
Vitamin D, Folate, and Cobalamin Serum Concentrations Are Related to Brain Volume and White Matter Integrity in Urban Adults
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DOI：
10.3389/fnagi.2020.00140
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发表时间：
2020-05-25
影响因子：
4.8
通讯作者：
Waldstein, Shari R.
中科院分区：
文献类型：
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作者：
Beydoun, May A.;Shaked, Danielle;Waldstein, Shari R.
背景和目标：较低的维生素水平与认知缺陷有关，有待机制阐明。探索血清 25-羟基维生素 D [25(OH)D]、叶酸和钴胺素对脑容量和白质完整性 (WMI) 的影响。方法：使用来自整个生命周期多样性社区健康老龄化 (HANDLS) 研究的三个前瞻性波[巴尔的摩市，马里兰州，2004-2015 年，N = 183-240 名城市成年人（年龄（v1）： 30-64岁）]。在第 1 次访视 (v(1): 2004-2009) 和第 2 次访视 (v(2): 2009-2013) 时测量血清维生素 25-羟基维生素 D [25(OH)D]、叶酸和钴胺素浓度，而在 v(scan): 2011-2015 时测量结构和扩散磁共振成像 (sMRI/dMRI) 结果。使用家庭 Bonferroni（FWER 50 岁：+205 +/- 54]；顶叶 WM；[总体：+251 +/- 77，男性：+486 +/- 129 和年龄（v1）> 50 岁：+393 +/- 108] 和左枕极体积 [总体：+15.70 +/- 108] 和左枕极体积（总体：+15.70 +/-）对排名前 10 名的调整关联进行校正。 3.83 及以上贫困：19.0 +/- 4.3]，重复了 25(OH)D (v(2)-v(1)) 年化暴露，这也与内囊前肢 (ALIC) 更大的 WMI（各向异性分数，FA）有关；FWER < 0.05 [总体：+0.0020 +/- 0.0004；白人： +0.0024 +/- 0.0004] 和扣带回（海马）[总体：+0.0016 +/- 0.0004] 只检测到钴胺素暴露的趋势 (q < 0.10)，而血清叶酸 (v(1)) 与 ALIC 中较低的平均扩散率 (MD) 相关，总体上反映了较高的 WMI。 25(OH)D 状态和增加始终与较大的枕叶和顶叶 WM 体积以及较大的区域特异性 WMI 相关，在我们的研究结果进行纵向复制之前，应针对大脑标志物结果进行维生素 D 补充剂的随机对照试验。
Background and objectives: Lower vitamin status has been linked to cognitive deficits, pending mechanistic elucidation. Serum 25-hydroxyvitamin D [25(OH)D], folate and cobalamin were explored against brain volumes and white matter integrity (WMI).Methods: Three prospective waves from Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) study were used [Baltimore, City, MD, 2004-2015, N = 183-240 urban adults (Age(v1): 30-64 years)]. Serum vitamin 25-hydroxyvitamin D [25(OH)D], folate and cobalamin concentrations were measured at visits 1 (v(1): 2004-2009) and 2 (v(2): 2009-2013), while structural and diffusion Magnetic Resonance Imaging (sMRI/dMRI) outcomes were measured at v(scan): 2011-2015. Top 10 ranked adjusted associations were corrected for multiple testing using familywise Bonferroni (FWER 50 years: +205 +/- 54]; parietal WM; [overall: +251 +/- 77, males: +486 +/- 129 and Age(v1) > 50 years: +393 +/- 108] and left occipital pole volume [overall: +15.70 +/- 3.83 and above poverty: 19.0 +/- 4.3], findings replicated for 25(OH)D (v(2)-v(1)) annualized exposure, which was also linked with greater WMI (fractional anisotropy, FA) in the anterior limb of the internal capsule (ALIC); FWER < 0.05 [Overall: +0.0020 +/- 0.0004; Whites: +0.0024 +/- 0.0004] and in the cingulum (hippocampus) [Overall: +0.0016 +/- 0.0004]. Only trends were detected for cobalamin exposures (q < 0.10), while serum folate (v(1)) was associated with lower mean diffusivity (MD) in ALIC, reflecting greater WMI, overall.Conclusions: Among urban adults, serum 25(OH)D status and increase were consistently linked to larger occipital and parietal WM volumes and greater region-specific WMI. Pending longitudinal replication of our findings, randomized controlled trials of vitamin D supplementation should be conducted against brain marker outcomes.