High-mobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma
High-mobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma
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DOI：
10.3892/mmr.2015.4182
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发表时间：
2015-10-01
影响因子：
3.4
通讯作者：
Song, Tao
中科院分区：
文献类型：
--
作者：
Liu, Zhikui;Dou, Changwei;Song, Tao
高迁移率族蛋白 1 (HMGB1) 是高迁移率族蛋白家族的成员，最初被定性为非组蛋白核 DNA 结合蛋白。虽然 HMGB1 在炎症和细胞分化中的作用先前已有报道，但其在肿瘤细胞迁移和侵袭中的作用，特别是在肝细胞癌 (HCC) 中的作用仍然难以捉摸。本研究报道，HCC组织中HMGB1的表达显着高于匹配的癌旁组织（P
High-mobility group box 1 (HMGB1), a member of the high-mobility group protein family, was originally characterized as a non-histone, nuclear DNA-binding protein. While the roles of HMGB1 in inflammation and cell differentiation have been previously reported, its role in tumor cell migration and invasion, particularly in hepatocellular carcinoma (HCC), has remained elusive. The present study reported that the expression of HMGB1 in HCC tissues was significantly higher than that in matched tumor-adjacent tissues (P