Exposure to anaesthetic agents, cognitive functioning and depressive symptomatology in the elderly
Exposure to anaesthetic agents, cognitive functioning and depressive symptomatology in the elderly
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DOI：
10.1192/bjp.178.4.360
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发表时间：
2001-04-01
影响因子：
10.5
通讯作者：
Ritchie, K
中科院分区：
文献类型：
--
作者：
Ancelin, ML;De Roquefeuil, G;Ritchie, K
背景麻醉可能会引起老年人特定认知领域的持续改变，其中与年龄相关的神经元变化可能会加剧药物毒性作用。Aims To evaluate anesthesia effects on the incidence of cognitive dysfunction after orthopaedic surgery in elderly patients. Methods A total of 140 patients over the age of 64 years completed a full range of computerized cognitive tests.该研究考虑到影响术前认知功能障碍，抑郁症和日常living.Results的活动能力，术后认知功能下降持续长达3个月的56%的科目。功能障碍仅限于言语、视觉空间和语义能力以及次级和内隐记忆。年龄教育水平低。术前认知功能障碍或抑郁症是危险因素。结论认知功能受到的影响并不相同，障碍类型由上述危险因素和麻醉类型决定。资金详情见鸣谢。
Background Anaesthesia could provoke persistent alterations in specific cognitive domains in the elderly where ageing-related neuronal changes may exacerbate pharmacotoxic effects.Aims To evaluate anaesthesia effects on the incidence of cognitive dysfunction after orthopaedic surgery in elderly patients.Method A total of 140 patients over the age of 64 years completed a full range of computerised cognitive tests. The study takes into account effects of pre-operative cognitive dysfunction, depressive symptomatology and ability to perform activities of daily living.Results Postoperative cognitive decline persisted for up to 3 months in 56% of subjects. Dysfunction was limited to verbal, visuo-spatial and semantic abilities and secondary and implicit memory. Age. low educational level. pre-operative cognitive impairment or depression are risk factors.Conclusions Cognitive functions are not equally affected, type of impairment being determined by the risk factors described above and anaesthesia type.Declaration of interest None. Funding detailed in Acknowledgements.