THE APPARENT INHIBITION OF SUPEROXIDE DISMUTASE ACTIVITY BY QUINONES
THE APPARENT INHIBITION OF SUPEROXIDE DISMUTASE ACTIVITY BY QUINONES
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DOI：
10.1016/0748-5514(86)90127-3
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发表时间：
1986-01-01
期刊：
影响因子：
--
通讯作者：
HOEY B M
中科院分区：
文献类型：
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作者：
BUTLER J;HOEY B M
已经证明，几种醌类化合物可以通过与超氧自由基发生平衡反应来改变牛铜超氧化物歧化酶的活性。这种明显的抑制的程度与醌类的单电子还原电位和半醌自由基/超氧自由基反应的平衡常数相关。各种速率常数已被估计，包括那些半醌自由基与细胞色素c和超氧化物歧化酶的反应。半醌自由基不能被超氧化物歧化酶歧化。
It has been demonstrated that several quinones can modify the activity of bovine copper superoxide dismutase by undergoing equilibrium reactions with superoxide radicals. The extent of this apparent inhibition correlates with the one electron reduction potentials of the quinones and the equilibrium constants of the semiquinone radical/superoxide radical reactions. Various rate constants have been estimated including those for the reactions of semiquinone radicals with cytochrome c and with superoxide dismutase. Semiquinone radicals cannot be dismutated by superoxide dismutase.