CHARACTERISTIC RESIDUAL NEUROPATHOLOGICAL FEATURES OF JAPANESE B-ENCEPHALITIS
CHARACTERISTIC RESIDUAL NEUROPATHOLOGICAL FEATURES OF JAPANESE B-ENCEPHALITIS
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DOI：
10.1007/bf00688063
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发表时间：
1977-01-01
影响因子：
12.7
通讯作者：
HAMADA, S
中科院分区：
文献类型：
--
作者：
ISHII, T;MATSUSHITA, M;HAMADA, S
本文报道4例确诊或疑似[人]乙型脑炎（JBE）的特征性残留（12-67岁）神经病理特征。这些特征总结为主要病变的独特分布模式，即丘脑、黑质和阿蒙角病变的组合。丘脑的病变始终以线性方式累及髓内板核和丘脑外侧核的邻近部分。黑质病变通常位于致密带的中部。这些病变通常对称，但范围不等。这种病变是独特的，特别是在丘脑和黑质。特征性光边界病灶（LCF），由小的稀疏区域组成，细胞和纤维成分很少，周围是致密的胶质间充质瘢痕，在那里观察到，偶尔在大脑皮层观察到。病变被认为是JBE急性期中枢神经系统报道的有边界的坏死灶的痕迹。丘脑病变的其他特征是钙化和双核神经细胞。未发现阿尔茨海默氏神经原纤维缠结。作者认为，裂口的分布和性质对诊断有一定的价值。
Characteristic residual (12-67 yr) neuropathological features of 4 verified or suspected [human] cases of Japanese B encephalitis (JBE) are reported. These features are summarized as unique distribution pattern of the main lesions, i.e., combination of lesions in the thalamus, substantia nigra and Ammon''s horn. Lesions in the thalamus consistently involved, in a linear fashion, lamina medullaris medialis with nucleus intralaminalis and adjacent portions of the nucleus lateralis thalami. Lesions in the substantia nigra usually occupied the middle parts of zona compacta. These lesions were usually symmetrical, though unequal in extent. The lesions are unique, especially those in the thalamus and substantia nigra. Characteristic light circumscribed foci (LCF), which consisted of small rarefied areas, with few cellular and fibrous elements, surrounded by dense gliomesenchymal scarring, were observed there and occasionally in cerebral cortices. Lesions were thought to be vestiges of circumscribed necrotic foci reported in the CNS of acute stage of JBE. Additional characteristic features in the thalamic lesions were calcified and binucleated nerve cells. Alzheimer''s neurofibrillary tangles were not found. Authors consider that the distribution and nature of the lisions are of disgnostic value.