The DAF-7 TGF-β signaling pathway regulates chemosensory receptor gene expression in C-elegans
The DAF-7 TGF-β signaling pathway regulates chemosensory receptor gene expression in C-elegans
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DOI：
10.1101/gad.1027702
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发表时间：
2002-12-01
影响因子：
10.5
通讯作者：
Sengupta, P
中科院分区：
文献类型：
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作者：
Nolan, KM;Sarafi-Reinach, TR;Sengupta, P
化学感受器基因表达对环境或发育线索的调节提供了一种机制，通过这种机制动物可以改变它们的感觉反应。在这里，我们证明了daf-7 TGF-β途径在秀丽隐杆线虫化学受体基因的一个子集的表达调控中的作用。我们描述了一种新的作用，这条途径在维持受体基因的表达在成人和显示，TGF-β 4 II型受体的功能细胞自主调节化学受体的表达。我们还发现，在ASI化学感觉神经元的受体基因表达的环境信号，如组成性产生的信息素的水平的改变，可以介导通过一个β-7-独立的途径。ASI和ASH感觉神经元中的受体基因表达似乎通过不同的机制进行调节。我们的研究结果表明，单个化学感受器基因的表达在C。秀丽隐杆线虫受到多种调节模式的影响，从而确保动物表现出最适合其发育阶段和环境条件的反应。
Regulation of chemoreceptor gene expression in response to environmental or developmental cues provides a mechanism by which animals can alter their sensory responses. Here we demonstrate a role for the daf-7 TGF-beta pathway in the regulation of expression of a subset of chemoreceptor genes in Caenorhabditis elegans. We describe a novel role of this pathway in maintaining receptor gene expression in the adult and show that the DAF-4 type II TGF-beta receptor functions cell-autonomously to modulate chemoreceptor expression. We also find that the alteration of receptor gene expression in the ASI chemosensory neurons by environmental signals, such as levels of a constitutively produced pheromone, may be mediated via a DAF-7-independent pathway. Receptor gene expression in the ASI and ASH sensory neurons appears to be regulated via distinct mechanisms. Our results suggest that the expression of individual chemoreceptor genes in C. elegans is subject to multiple modes of regulation, thereby ensuring that animals exhibit the responses most appropriate for their developmental stage and environmental conditions.