Febrile seizures and epilepsy: the contributions of epidemiology.
Febrile seizures and epilepsy: the contributions of epidemiology.
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DOI：
10.1111/j.1365-3016.1992.tb00756.x
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发表时间：
1992-04-01
影响因子：
2.8
通讯作者：
Berg, A T
中科院分区：
文献类型：
--
作者：
Berg, A T
在过去，热性惊厥被认为是癫痫的一种征兆，癫痫是一种以反复无端惊厥为特征的疾病。目前，热性癫痫被认为是一种不同于癫痫的良性发作综合征。这种区分之所以成为可能，很大程度上是因为流行病学证据，这里以两部分论证的形式提出了这些证据。如果热性惊厥是癫痫，人们可能会期望：(1)在第一次热性惊厥之后，第二次热性惊厥的风险应该与非诱发性惊厥的风险相似（事实上，反复发生热性惊厥的风险约为34%，而发生热性惊厥后再次发生非诱发性惊厥的风险约为2%至3%）；(2)预测反复热性惊厥的因素也应预测随后的无因性惊厥。从现有文献来看，第一次热性惊厥时的年轻年龄和热性惊厥家族史可预测反复的热性惊厥，但不能预测随后的非诱发性惊厥。相反，癫痫家族史、复杂热性发作和神经异常与继发癫痫的风险增加相关，但与复发热性发作的风险并不一致。
In the past, febrile seizures were considered to be a sign of epilepsy, a disorder characterised by recurrent unprovoked seizures. Currently, febrile seizures are considered to be a benign seizure syndrome that is distinct from epilepsy. This distinction has been possible largely because of the epidemiological evidence which is presented here in the form of a two-part argument. If febrile seizures are epilepsy one might expect that: (1) following a first febrile seizure, the risk of a second febrile seizure should be similar to the risk of an unprovoked seizure (in fact, the risk of a recurrent febrile seizure is approximately 34%, whereas the risk of an unprovoked seizure after having had a febrile seizure is approximately 2% to 3%); (2) the factors that predict recurrent febrile seizures should also predict subsequent unprovoked seizures. From the available literature, young age at the time of the first febrile seizure and a family history of febrile seizures predict recurrent febrile seizures, but do not predict subsequent unprovoked seizures. By contrast, a family history of epilepsy, complex febrile seizures and neurological abnormality are associated with an increased risk of subsequent epilepsy but are not consistently associated with the risk of a recurrent febrile seizure.