SKELETAL-MUSCLE COMPOSITION IN DIETARY OBESITY-SUSCEPTIBLE AND DIETARY OBESITY-RESISTANT RATS
SKELETAL-MUSCLE COMPOSITION IN DIETARY OBESITY-SUSCEPTIBLE AND DIETARY OBESITY-RESISTANT RATS
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DOI：
10.1152/ajpregu.1992.262.4.r684
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发表时间：
1992-04-01
影响因子：
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通讯作者：
HILL, JO
中科院分区：
文献类型：
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作者：
MRAD, JA;YAKUBU, F;HILL, JO
本研究的目的是确定高脂饮食（HFD）诱导的肥胖症的易感性和骨骼肌纤维类型之间是否存在关系。 44只成年雄性Wistar大鼠自由进食HFD（60%的热量来自脂肪）4周。 然后将大鼠按总体重增加分为四分位数，并将上四分位数[肥胖倾向（OP）]大鼠与下四分位数[肥胖抵抗（OR）]大鼠进行比较。 OP大鼠的体重增加是OR大鼠的1.5倍。 OR大鼠腓肠肌内侧头中I型肌纤维的比例显著高于OP大鼠，无论是在HFD喂养期之前（从肌肉活检确定）还是之后。 更大比例的I型纤维可能与更大的脂肪氧化能力有关，这将有利于抵抗体脂肪积累。 肌纤维组成的预先存在的差异可能在确定饮食性肥胖的易感性方面发挥作用。
The intent of this study was to determine whether a relationship exists between susceptibility to high-fat diet (HFD)-induced obesity and skeletal muscle fiber type. Forty-four adult male Wistar rats were given ad libitum access to a HFD (60% of calories from fat) for 4 wk. Rats were then grouped into quartiles for total weight gain, and the top-quartile [obesity prone (OP)] rats were compared with the bottom-quartile [obesity resistant (OR)] rats. OP rats gained 1.5 times as much weight as OR rats. OR rats had a significantly higher proportion of type I muscle fibers in the medial head of the gastrocnemius muscle than OP rats both before (determined from a muscle biopsy) and after the HFD feeding period. A greater proportion of type I fibers may be associated with a greater capacity for fat oxidation, which would favor resistance to body fat accumulation. Preexisting differences in muscle fiber composition may play a role in determining susceptibility to dietary obesity.