The vascular densities of the macula and optic disc in normal eyes from children by optical coherence tomography angiography
The vascular densities of the macula and optic disc in normal eyes from children by optical coherence tomography angiography
复制标题
通过光学相干断层扫描血管造影观察正常儿童眼黄斑和视神经盘的血管密度。
DOI：
10.1007/s00417-019-04466-0
复制
发表时间：
2020-02-01
影响因子：
2.7
通讯作者：
Lan, Yuqing
中科院分区：
文献类型：
--
作者：
Zhang, Yichi;Zhang, Bihong;Lan, Yuqing
目的探讨正常儿童黄斑和视盘血管密度（VD）的变化及特点。方法回顾性研究5-18岁正常眼的视力。采用光学相干断层扫描血管造影（OCTA）对黄斑和视盘进行扫描。分析年龄、性别、眼轴长度对VD的影响。结果71例71只眼正常人眼均入选。在黄斑区，视网膜浅层的中心凹、旁中心凹和中心凹周围的平均VD分别为20.1%、50.2%、49.4%、36.1%、53.9%和48.1%。平均中心凹无血管区（FAZ）为0.277 mm（2）。视盘放射状毛细血管（RPC）和视盘内侧区的平均VD分别为51.8%和51.7%。在浅视网膜旁裂、深视网膜中央凹周围和中央凹周围的上半和后半VD之间发现了显著差异。视网膜浅、深凹及FAZ区的VD存在性别差异。结论浅部视网膜旁、深部视网膜旁、深部视网膜中心凹周围存在上半侧VD;男孩中心凹VD高于女孩，FAZ面积小于女孩; 5-18岁儿童黄斑部VD和视乳头周围RPC密度较稳定。本研究为进一步了解儿童血管发育模式和儿童OCTA的临床应用提供了有益的信息。
Purpose This study aims to describe the variation and characteristics of vessel density (VD) of the macula and optic disc in the normal eyes of children. Methods This was a retrospective study where subjects aged 5-18 years with normal eyes were enrolled. The macula and optic disc were scanned by optical coherence tomography angiography (OCTA). The influences of age, gender, and axial length (AL) on VD were analyzed. Results A total of 71 normal eyes from 71 subjects were enrolled. For the macula, the mean VD of fovea, parafovea, and perifovea at superficial retina and deep retina were 20.1%, 50.2%, 49.4%, 36.1%, 53.9%, and 48.1%, respectively. The mean foveal avascular zone (FAZ) was 0.277 mm(2). For optic disc, the mean VD of radial peripapillary capillary (RPC) and inside-disc areas were 51.8% and 51.7%, respectively. Significant differences were found between the superior-hemi and inferior-hemi VD of the superficial retinal parafovea, deep retinal perifovea, and perifovea. The fovea VD of the superficial and deep retina and FAZ areas were different between genders. The inside-disc VD was positively correlated with AL, while other VDs had no significant correlation with age and AL. Conclusions The parafovea VD of the superficial retina, parafovea, and perifovea of the deep retina had superior-hemi VD; boys had a higher fovea VD and smaller FAZ area than those of girls, the macular VD and peripapillary RPC density were steady for 5-18 year-olds. This study provided useful information for furthering the understanding of the development mode of vessel in children and the OCTA clinical applications in children.