Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements
Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements
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DOI：
10.1038/s41598-019-46630-w
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发表时间：
2019-07-25
影响因子：
4.6
通讯作者：
Jaroszynski, D. A.
中科院分区：
文献类型：
--
作者：
Kokurewicz, K.;Brunetti, E.;Jaroszynski, D. A.
由于相对论效应，极高能电子（VHEE）的惯性增加，减少了散射，并使深层肿瘤的照射成为可能。然而，入射和出射剂量对于准直或发散光束是高的。在这里，我们进行了一项研究的基础上的Monte Carlo模拟聚焦VHEE光束在水的幻影，显示剂量可以集中到一个小的，定义明确的体积元素，可以成形或扫描治疗深层次的肿瘤。对周围组织的剂量分布在较大的体积上，与准直光束相比，这将单个光束的峰值表面和出射剂量降低了一个数量级以上。
The increased inertia of very high-energy electrons (VHEEs) due to relativistic effects reduces scattering and enables irradiation of deep-seated tumours. However, entrance and exit doses are high for collimated or diverging beams. Here, we perform a study based on Monte Carlo simulations of focused VHEE beams in a water phantom, showing that dose can be concentrated into a small, well-defined volumetric element, which can be shaped or scanned to treat deep-seated tumours. The dose to surrounding tissue is distributed over a larger volume, which reduces peak surface and exit doses for a single beam by more than one order of magnitude compared with a collimated beam.