The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms
The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms
复制标题
促食欲激素基因多态性对创伤后应激障碍症状的初步研究
DOI：
10.1016/j.psyneuen.2018.09.042
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发表时间：
2019
影响因子：
3.7
通讯作者：
Liberzone Israel
中科院分区：
文献类型：
--
作者：
Li Gen;Zhang Kunlin;Wang Li;Cao Chengqi;Fang Ruojiao;Liu Ping;Luo Shu;Liberzone Israel
Orexigenic hormones are a group of hormones that can up-regulate appetite. Current studies have shown that orexigenic hormones also play important roles in stress responses and may be implicated in regulation of fear memory. However, these conclusions lack evidence from human studies. In this study, we examined associations between orexigenic hormone genes and fear-related mental disorders by investigating main, G × E, and G × G effects of ghrelin and orexin gene single nucleotide polymorphisms (SNPs) on human posttraumatic stress disorder (PTSD) symptoms in 1134 Chinese earthquake survivors. SNPs Leu72Met of theGHRLgene (rs696217), Ile408Val of theHCRTR1gene (rs2271933) and Val308Ile of theHCRTR2gene (rs2653349) were genotyped. None of the SNPs showed significant main or G × E effects. However, a significant interaction effect betweenGHRLrs696217 andHCRTR1rs2271933 was found to predict the PTSD Checklist (PCL-5) total score (P= 0.007). Further analysis revealed different interaction patterns in males and females. For females, the rs2271933 G allele was associated with an increased PCL-5 total score (B = 2.59,P= 0.024) when the rs696217 genotype TT/TG was present. For males, the rs696217 T allele is associated with an increased PCL-5 total score (B = 3.62,P= 0.040) when the rs2271933 genotype GG/GA was present. These current findings expand our knowledge of physiological function of the orexigenic hormone system, and suggest its involvement in development of fear-related mental disorders such as PTSD.
