Plasma E-selectin levels can play a role in the development of diabetic retinopathy
Plasma E-selectin levels can play a role in the development of diabetic retinopathy
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DOI：
10.1007/s00417-016-3411-1
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发表时间：
2017-01-01
影响因子：
2.7
通讯作者：
Nagy, V.
中科院分区：
文献类型：
--
作者：
Kasza, Marta;Meleg, J.;Nagy, V.
糖尿病视网膜病变是导致失明的主要原因之一。有几个风险因素，如糖尿病的持续时间或患者的血糖控制;然而，几个生化因素也会改变这一过程。为探讨可溶性E-选择素在糖尿病视网膜病变形成中的作用，选择57例糖尿病视网膜病变患者（女性37例，男性20例，年龄61.71 ± 12.31岁）和14例健康对照者（女性10例，男性4例，年龄63.06 ± 10.46岁）。我们通过ELISA法测定了患者血浆中可溶性E-选择素水平。所有患者均接受了仔细的眼科检查，包括眼底镜检查和彩色眼底照相，同时根据美国眼科学会（AAO）2012年的分类进行糖尿病视网膜病变分级。与对照组相比，糖尿病患者的可溶性E-选择素水平显著较高（32.95 ng/ml vs. 26.55 ng/ml，p = 0.03）。根据是否存在视网膜病变将患者分组，视网膜病变组的E-选择素水平也显著较高（p < 0.05）。然而，当我们根据视网膜病变的严重程度检查糖尿病患者时（根据AAO的指南，分为A、B和C组），我们没有发现可溶性E-选择素水平的任何显著差异，尽管B组中可溶性E-选择素水平倾向于更高。E-选择素水平升高可能在糖尿病视网膜病变的发展中起作用，但似乎并不改变疾病的严重程度。然而，血糖控制和心血管危险因素的减少也可能改变E-选择素的水平，这可能在预防糖尿病视网膜病变中发挥作用。
Diabetic retinopathy is one of the leading causes of blindness. There are several risk factors, such as the duration of diabetes or glycemic control of the patient; however, several biochemical factors also alter the process. Our aim was to investigate the role of soluble E-selectin in the formation of diabetic retinopathy.Fifty-seven patients (37 female and 20 male, aged 61.71 +/- 12.31 years) and 14 healthy control subjects (ten female and four male, aged 63.06 +/- 10.46 years) were enrolled in the study. We measured the soluble E-selectin level in the plasma of patients by ELISA. All patients underwent careful ophthalmological examination, including ophthalmoscopy and color fundus photography, while diabetic retinopathy grading was performed in line with the 2012 classification of the American Academy of Ophthalmology (AAO).The soluble E-selectin level was significantly higher in patients with diabetes compared to controls (32.95 ng/ml vs. 26.55 ng/ml, p = 0.03). Dividing patients into groups by the presence of retinopathy, the E-selectin level was also significantly higher in the retinopathy group (p < 0.05). When we examined diabetic patients by the severity of retinopathy (groups A, B, and C, by the guidelines of the AAO), however, we did not find any significant difference in soluble E-selectin levels, although it tended to be higher in group B.An elevated E-selectin level can play a role in the development of diabetic retinopathy, but it does not seem to alter disease severity. However, glycemic control and the reduction of cardiovascular risk factors may also alter the level of E-selectin that might play a role in the prevention of diabetic retinopathy.