Liriopis tuber inhibit OVA-induced airway inflammation and bronchial hyperresponsiveness in murine model of asthma
Liriopis tuber inhibit OVA-induced airway inflammation and bronchial hyperresponsiveness in murine model of asthma
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DOI：
10.1016/j.jep.2005.04.030
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发表时间：
2005-10-03
影响因子：
5.4
通讯作者：
Kook, YB
中科院分区：
文献类型：
--
作者：
Lee, YC;Lee, JC;Kook, YB
白叶山麦冬是东方医学中用于治疗哮喘、支气管炎和肺部炎症的著名草本植物之一。白叶麦冬在OVA诱导的呼吸道炎症和小鼠哮喘模型中的平喘作用尚未得到充分的活体研究。哮喘是一种慢性黏膜炎症性疾病，与Th2细胞因子的过度产生和嗜酸性粒细胞在肺内的聚集有关。为了阐明白叶麦冬的抗炎和平喘作用，我们观察了山麦冬对哮喘小鼠肺嗜酸性炎症发展的影响。结果表明，山麦冬通过降低BALF和血清中IL-5、IL-13、IL-4和IgE的水平，使嗜酸性粒细胞聚集到呼吸道，减少嗜酸性粒细胞，减少肺白细胞总数。此外，LRT还可降低肺细胞嗜酸性粒细胞CCR3和CD11b的表达。这些结果表明，LRT对哮喘小鼠的气道炎症和高反应性有明显的抑制作用，并通过调节Th1/Th2细胞因子失衡的关系，发挥免疫调节作用，具有抗炎、平喘的作用。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
Liriope platyphylla is one of the well-known herb used in oriental medicine for treatment asthma and bronchial and lung inflammation. Anti-asthmatic effects of Liriope platyphylla in the development of OVA-induced airway inflammation and murine asthma model have not been fully investigated in vivo.Asthma is a chronic inflammatory disease of the mucosa and is associated with excess production of Th2 cytokines and eosinophil accumulation in lung. To clarify the anti-inflammatory and anti-asthmatic effects of Liriope platyphylla, we examined the influence of liriopis tuber (LRT) on the development of pulmonary eosinophilic inflammation in murine model of asthma.Our results have shown that LRT were demonstrated on the accumulation of eosinophills into airways, with reduction of eosinophil, total lung leukocytes numbers by reduction IL-5, IL-13, IL-4 and IgE levels in the BALF and serum. Moreover, LRT decreased eosinophil CCR3 expression and CD11b expression in lung cells. These results indicate that LRT has a deep inhibitory effects on airway inflammation and hyperresponsiveness in murine model of asthma and play an crucial role as a immunomodulator which possess anti-inflammatory and anti-asthmatic property by modulating the relationship between Th1/Th2 cytokine imbalance. (C) 2005 Elsevier Ireland Ltd. All rights reserved.