Pemetrexed for epithelioid haemangioendothelioma of the pleura.
Pemetrexed for epithelioid haemangioendothelioma of the pleura.
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DOI：
10.1002/rcr2.191
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发表时间：
2016-11
影响因子：
0.8
通讯作者：
Nakano, Takashi
中科院分区：
文献类型：
--
作者：
Kanemura, Shingo;Kuribayashi, Kozo;Moriya, Yumiko;Shimizu, Shigeki;Tsujimura, Tohru;Nakano, Takashi
一名31岁女性有2个月的左背痛病史。胸部X线片显示左肺尖胸膜增厚，而胸部计算机断层扫描显示左胸腔积液伴弥漫性胸膜增厚。根据这些发现，怀疑恶性间皮瘤。进行了电视胸腔镜胸膜活检，随后的标本染色显示抗细胞角蛋白抗体结果为阴性，血管内皮免疫组织化学标记物结果为阳性。因此，诊断为上皮样血管内皮瘤（EHE），并开始卡铂、培美曲塞和贝伐单抗化疗。第四个疗程后，疾病得到良好控制，左侧胸腔积液减少90%。此病例非常罕见，因为EHE起源于胸膜。此外，尚无培美曲塞治疗EHE的报告。
A 31‐year‐old woman presented with a 2‐month history of dull left back pain. Chest roentgenography revealed pleural thickening in the left lung apex, whereas chest computed tomography showed a left pleural effusion with diffuse pleural thickening. Based on these findings, malignant mesothelioma was suspected. Video‐assisted thoracoscopic pleural biopsy was performed, and subsequent staining of the specimen revealed negative results for anti‐cytokeratin antibodies and positive results for vascular endothelial immunohistochemical markers. Therefore, a diagnosis of epithelioid hemangioendothelioma (EHE) was made, and chemotherapy with carboplatin, pemetrexed, and bevacizumab was initiated. After the fourth course of treatment, the disease was well controlled with a 90% reduction of the left pleural effusion. This case is very rare in that the EHE originated from the pleura. Additionally, there has been no report of pemetrexed for treatment of EHE.