Olfaction and social drive in schizophrenia
Olfaction and social drive in schizophrenia
复制标题
DOI：
10.1001/archpsyc.60.6.578
复制
发表时间：
2003-06-01
影响因子：
--
通讯作者：
Coleman, E
中科院分区：
文献类型：
--
作者：
Malaspina, D;Coleman, E
背景：精神分裂症患者社交功能障碍的神经生物学机制尚不清楚，但嗅觉识别缺陷（SIDs）在精神分裂症患者中存在，嗅觉与其他哺乳动物的社交关系有关。小岛屿发展障碍与阴性症状和缺陷综合症有关，但小岛屿发展障碍与社会功能障碍的任何特异性尚未研究。低智商可以解释这种关系，如果它与阴性症状和小岛屿发展障碍有关的话。我们研究了精神分裂症中的小岛屿发育障碍是否与阴性症状广泛相关，就像许多其他神经心理学指标一样，或者它们是否可能与社会驱动力表现出更具体的关系。方法：对70例DSM-IV型精神分裂症患者嗅觉识别测验得分、韦氏成人智力量表-修正智商、正负证量表及缺陷证进行分析。小岛屿发展中国家与消极症状和缺陷综合症有关，但小岛屿发展中国家与社会驱动力减弱的联系解释了这两种关系。嗅觉识别也与韦氏成人智力量表修正版的智商有关，但智力与SID和社会驱力的关系无关。男性患者嗅觉识别测试成绩较差的原因是男性中嗅觉缺陷综合症患者的比例更大。结论：这些分析证明了嗅觉识别测试分数与社会驱动力和智力之间的独立关系，它们共同占嗅觉识别测试分数差异的近50%。精神分裂症患者的低社会驱力和小岛屿发育障碍可能存在共同的神经基础。
Background: The neurobiology of social dysfunction in Schizophrenia is unknown, but smell identification deficits (SIDs) exist in schizophrenia, and olfaction is related to social affiliation in other mammals. The SIDs have been linked with negative symptoms and the deficit syndrome, but any specificity of SIDs for social dysfunction is unstudied. Low intelligence might explain this relationship, if it is associated with both negative symptoms and SIDs. We examined whether SIDs in schizophrenia were related broadly to negative symptoms, as are a number of other neuropsychological measures, or whether they might show a more specific relationship with social drive.Methods: Smell Identification Test scores, Wechsler Adult Intelligence Scale-Revised IQ, symptomatology assessed with the Positive and Negative Syndrome Scale and the deficit syndrome were determined in 70 patients with DSM-IV schizophrenia.Results; The SIDs were related to negative symptoms and the deficit syndrome, but the association of SIDs With diminished social drive explained both relationships. Smell identification was also related to Wechsler Adult Intelligence Scale-Revised IQ, but intelligence was independent of the relationship of SID and social drive. The worse Smell Identification Test scores in male patients were attributable to a greater preponderance of men with the deficit syndrome.Conclusions: These analyses demonstrated independent relationships of Smell Identification Test scores to social drive and intelligence that together accounted for almost 50% of the variance in Smell Identification Test scores. There may be common neural substrates for the low Social drive and SIDs in schizophrenia.