Double minute chromosomes and the homogeneously staining regions in chromosomes of a human neuroblastoma cell line.
Double minute chromosomes and the homogeneously staining regions in chromosomes of a human neuroblastoma cell line.
复制标题
双微小染色体和人神经母细胞瘤细胞系染色体中的均匀染色区域。
作者：
G. Balaban;F. Gilbert
用染色体显带技术对4个人神经母细胞瘤细胞系进行了研究。所有品系都含有一个标记染色体，带有一个长的非显带均匀染色区域(HSR)。含有HSR的染色体在每一株系中都不同。其中一个品系含有两类细胞：一类具有HST标记染色体，另一类具有双微染色体。每个细胞都有其中一种异常；没有细胞同时具有这两种异常。在该品系的所有细胞中存在两个额外的染色体标记，表明有共同的起源。这些观察结果表明，双小染色体起源于HSR。
Four human neuroblastoma cell lines were studied by chromosome banding techniques. All of the lines contained a marker chromosome with a long nonbanding homogeneously staining region (HSR). The HSR-containing chromosome differed in each line. One line contained two classes of cells: one with an HST marker chromosome and the other with double minute chromosomes. Each cell had one of these abnormalities; no cell had both. The presence of two additional chromosomal markers in all cells of this line indicates a common origin. These observations suggest that the double minute chromosomes are derived from the HSR.