Morphogenesis and renewal of hair follicles from adult multipotent stem cells
Morphogenesis and renewal of hair follicles from adult multipotent stem cells
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DOI：
10.1016/s0092-8674(01)00208-2
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发表时间：
2001-01-26
期刊：
影响因子：
64.5
通讯作者：
Barrandon, Y
中科院分区：
文献类型：
--
作者：
Oshima, H;Rochat, A;Barrandon, Y
成年小鼠触须毛囊外根鞘的上部含有多能干细胞，它们对形态发生信号做出反应，生成多个毛囊、皮脂腺和表皮，即毛皮的所有谱系。当毛发生产停止时，当毛囊的下部区域经历主要的结构变化时，下部区域包含大量克隆性角质形成细胞，然后可以对形态发生信号做出反应。这表明，多能干细胞迁移到毛囊的根部，以产生胡须生长。此外，我们的结果表明，克隆性角质形成细胞与多能干细胞即使不是完全相同，也是密切相关的，而且调控胡须生长需要精确控制干细胞的运输。
The upper region of the outer root sheath of vibrissal follicles of adult mice contains multipotent stem cells that respond to morphogenetic signals to generate multiple hair follicles, sebaceous glands, and epidermis, i.e., all the lineages of the hairy skin. At the time when hair production ceases and when the lower region of the follicle undergoes major structural changes, the lower region contains a significant number of clonogenic keratinocytes, and can then respond to morphogenetic signals. This demonstrates that multipotent stem cells migrate to the root of the follicle to produce whisker growth. Moreover, our results indicate that the clonogenic keratinocytes are closely related, if not identical, to the multipotent stem cells, and that the regulation of whisker growth necessitates a precise control of stem cell trafficking.