Adding a "Notch" to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach.
Adding a "Notch" to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach.
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在心血管疾病疗法中添加“缺口”：一种基于microRNA的方法。
DOI：
10.3389/fcell.2021.695114
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发表时间：
2021
影响因子：
5.5
通讯作者：
Rizzo P
中科院分区：
文献类型：
--
作者：
Marracino L;Fortini F;Bouhamida E;Camponogara F;Severi P;Mazzoni E;Patergnani S;D'Aniello E;Campana R;Pinton P;Martini F;Tognon M;Campo G;Ferrari R;Vieceli Dalla Sega F;Rizzo P
Notch通路的失调与心血管疾病（cvd）的病理生理有关，但是，到目前为止，基于重建心脏和血管中Notch生理水平的治疗还不可用。一个可能的原因是Notch在心血管系统中的环境依赖性作用，这需要一种精细调整的、细胞特异性的方法。MicroRNAs （miRNAs）是短的功能性内源性非编码RNA序列，能够在转录后水平调节基因表达，影响大多数（如果不是全部）生物过程。mirna表达的失调与许多心血管疾病的分子机制有关。Notch受心血管系统中大量mirna表达的调控，因此，靶向这些mirna可能是探索靶向Notch治疗心血管疾病的一条途径。在这篇综述中，基于其他病理证据，我们概述了mirna和Notch在动脉粥样硬化、心肌缺血、心力衰竭、主动脉瓣钙化和心律失常的细胞过程中的串扰。我们还讨论了使用mirna作为一种基于notch的方法来诊断和治疗最常见的心血管疾病的潜在优势和挑战。
Dysregulation of the Notch pathway is implicated in the pathophysiology of cardiovascular diseases (CVDs), but, as of today, therapies based on the re-establishing the physiological levels of Notch in the heart and vessels are not available. A possible reason is the context-dependent role of Notch in the cardiovascular system, which would require a finely tuned, cell-specific approach. MicroRNAs (miRNAs) are short functional endogenous, non-coding RNA sequences able to regulate gene expression at post-transcriptional levels influencing most, if not all, biological processes. Dysregulation of miRNAs expression is implicated in the molecular mechanisms underlying many CVDs. Notch is regulated and regulates a large number of miRNAs expressed in the cardiovascular system and, thus, targeting these miRNAs could represent an avenue to be explored to target Notch for CVDs. In this Review, we provide an overview of both established and potential, based on evidence in other pathologies, crosstalks between miRNAs and Notch in cellular processes underlying atherosclerosis, myocardial ischemia, heart failure, calcification of aortic valve, and arrhythmias. We also discuss the potential advantages, as well as the challenges, of using miRNAs for a Notch-based approach for the diagnosis and treatment of the most common CVDs.
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影响因子：
12.4
作者：
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通讯作者：
Liu Y
影响因子：
7.4
作者：
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通讯作者：
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影响因子：
4.8
作者：
Boucher, Joshua M.;Peterson, Sarah M.;Liaw, Lucy
通讯作者：
Liaw, Lucy
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DOI：
10.1083/jcb.200806104
发表时间：
2008-10-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Campa VM;Gutiérrez-Lanza R;Cerignoli F;Díaz-Trelles R;Nelson B;Tsuji T;Barcova M;Jiang W;Mercola M
通讯作者：
Mercola M
影响因子：
4.6
作者：
Cerutti C;Edwards LJ;de Vries HE;Sharrack B;Male DK;Romero IA
通讯作者：
Romero IA