Prevalence of cystoid macular edema and stability in OCT retinal thickness in eyes with retinitis pigmentosa during a 48-week lutein trial
Prevalence of cystoid macular edema and stability in OCT retinal thickness in eyes with retinitis pigmentosa during a 48-week lutein trial
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DOI：
10.1097/iae.0b013e31809862aa
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发表时间：
2008-01-01
影响因子：
3.3
通讯作者：
Dagnelie, Gislin
中科院分区：
文献类型：
--
作者：
Adackapara, Cheryl A.;Sunness, Janet S.;Dagnelie, Gislin
目的：描述一组中度晚期视网膜色素变性（RP）患者黄斑囊样水肿（CME）的患病率、48周内中心凹厚度的变化、视力（VA）与视网膜厚度的相关性以及CME对叶黄素给药缺乏反应。方法：对39例（77眼）RP患者的黄斑光学相干断层扫描（OCT）成像和临床检查进行了评价，时间超过11个月，每6周进行一次扫描。CME的患病率（由OCT可见的囊肿定义）为49%。44%的患者（39例中的17例）出现双侧CME，另外2例患者出现单侧CME。视网膜中央厚度在48周内变化不大。66%患有CME的眼睛视力为20/40或更好。视力差于20/40的CME眼要么增厚程度更大，要么实际上厚度测量值更低。对于没有CME的眼睛，视力差于20/40的眼睛往往比视力为20/40或更好的眼睛具有更低的视网膜厚度。视力高度一致的眼睛之间，并没有显着差异组和无CME。叶黄素对有或无CME患者的视网膜厚度无统计学显著影响，视力好或差于20/40的患者亚组中也未观察到这种影响。结论：CME的患病率高于以往的报道，可能是因为患者有一定的黄斑视力保留，并且使用了基于OCT结果的定义。视网膜厚度随着时间的推移保持相当稳定，在患有CME的眼睛和没有CME的眼睛中都是如此。
Purpose: To describe, in a group of patients with moderately advanced retinitis pigmentosa (RP), the prevalence of cystoid macular edema (CME), the variation in foveal thickness over a 48-week period, the correlation of visual acuity (VA) with retinal thickness, and the lack of response of CME to lutein administration.Methods: Optical coherence tomography (OCT) imaging of the macula and clinical examination were evaluated for 77 eyes of 39 patients with RP over 11 months, with a scan done every 6 weeks.Results: The prevalence of CME, defined by cysts visible on OCT, was 49%. Bilateral CME was present in 44% of patients (17 of 39), and an additional two patients had unilateral CME. Central retinal thickness varied little over the 48 weeks. Sixty-six percent of the eyes with CME had VA of 20/40 or better. The eyes with CME with VA worse than 20/40 had either greater degrees of thickening or in fact had lower thickness measures. For the eyes without CME, the eyes with VA worse than 20/40 tended to have lower retinal thickness than the eyes with VA of 20/40 or better. VA was highly concordant between eyes, and did not differ significantly between the groups with and without CME. Lutein did not show a statistically significant effect on retinal thickness in the patients with or without CME, nor was such an effect observed in subgroups of patients with vision better or worse than 20/40.Conclusion: The prevalence rate of CME is higher than in previous reports, perhaps because the patients had some preserved macular vision and because of the use of a definition based on OCT findings. Retinal thickness remains fairly stable over time, both in eyes with CME and in eyes without CME.