Direct electrical single-molecule detection of DNA through electron transfer induced by hybridization
Direct electrical single-molecule detection of DNA through electron transfer induced by hybridization
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DOI：
10.1039/c3cc38992h
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Phuc Tan Bui
中科院分区：
文献类型：
--
作者：
Nishino, Tomoaki;Phuc Tan Bui
利用单链DNA作为探针尖端进行单分子DNA检测。DNA尖端和靶DNA的杂交诱导电子隧穿通过所得DNA双链体。它表明，DNA尖端不仅允许基因检测，但也发现单核苷酸多态性在单分子水平。
Single-stranded DNA was utilized as a probe tip for single-molecule DNA detection. Hybridization of the DNA tip and target DNA induces electron tunneling through the resulting DNA duplex. It is demonstrated that the DNA tip allows not only genetic detection but also discovery of single-nucleotide polymorphisms at the single-molecule level.