Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia.
Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia.
复制标题
路易体痴呆和帕金森病痴呆的认知和运动下降。
DOI：
10.1002/mdc3.13752
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发表时间：
2023
影响因子：
4
通讯作者：
Gonzalez MC
中科院分区：
文献类型：
--
作者：
Gonzalez MC
目的比较E-路易体痴呆组和帕金森氏病痴呆组患者的认知和运动功能减退的发生率。方法采用线性混合回归模型估计至少有一次随访( =DLBn= 837和PDDn=P157.)的路易体痴呆和帕金森病痴呆患者的认知和运动功能减退的发生率。−1.8[95%CI−2.3，−1.3]与−1.9[95%CI−2.6，−1.2][P= 0.74]。DLB4.8[95%CI2.1，7.5](PDD4.8[95%CI2.7，6.9]，[P= 0.98])。这对未来的临床试验设计是相关的。
BackgroundThere is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD).ObjectivesTo compare the rate of cognitive and motor decline in patients with DLB and PDD from the E‐DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts.MethodsThe annual change in MMSE and MDS‐UPDRS part III was estimated using linear mixed regression models in patients with at least one follow‐up (DLBn= 837 and PDDn= 157).ResultsWhen adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (−1.8 [95% CI −2.3, −1.3] vs. −1.9 [95% CI −2.6, −1.2] [P= 0.74]). MDS‐UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P= 0.98]).ConclusionsDLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.