Abnormal adrenergic and cholinergic sensitivity in cystic fibrosis.
Abnormal adrenergic and cholinergic sensitivity in cystic fibrosis.
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囊性纤维化中肾上腺素能和胆碱能敏感性异常。
DOI：
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发表时间：
1980
影响因子：
158.5
通讯作者：
M. Kaliner
中科院分区：
文献类型：
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作者：
P. Davis;J. Shelhamer;M. Kaliner
最明显受囊性纤维化影响的器官系统部分受到自主神经系统的调节。异常的自主神经调节可能导致囊性纤维化的临床谱。1，2先前的研究表明，瞳孔中的α-肾上腺素能调节可能异常，3，4白细胞中的β-肾上腺素能反应异常，5并且对胆碱能药物的反应可能在颌下腺6和支气管平滑肌中紊乱。7，8因此，在囊性纤维化中，自主神经系统的所有三种成分的异常可能共存。这些观察结果的一个可能解释是终末器官的反应性改变。为了评估这种可能性，
THE organ systems most clearly affected by cystic fibrosis are regulated in part by the autonomic nervous system. Abnormal autonomic regulation may contribute to the clinical spectrum of cystic fibrosis.1 , 2 Previous studies have suggested that alpha-adrenergic regulation may be abnormal in the pupils,3 , 4 that beta-adrenergic responses are abnormal in leukocytes,5 and that responses to cholinergic agents may be disordered in the submaxillary gland6 and bronchial smooth muscle.7 , 8 Thus, abnormalities in all three components of the autonomic nervous system may coexist in cystic fibrosis. One possible explanation for these observations is altered responsiveness of the end organs. To assess this possibility, . . .