Signal transduction through lipid second messengers
Signal transduction through lipid second messengers
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DOI：
10.1016/s0955-0674(96)80061-5
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发表时间：
1996-04-01
影响因子：
7.5
通讯作者：
Kolesnick, R
中科院分区：
文献类型：
--
作者：
Spiegel, S;Foster, D;Kolesnick, R
本文就甘油脂和鞘脂第二信使的产生及其分子靶点作一综述。讨论了磷脂酰肌醇转移蛋白和磷脂酶D在信号传递中的作用，以及蛋白激酶C的1,2-二酰基甘油和钙结合位点的结构。此外，通过蛋白激酶的神经酰胺信号传导和串扰在细胞凋亡和炎症信号传导中的作用得到了解决。
This review emphasizes the generation of glycerolipid and sphingolipid second messengers, and their molecular targets. The role of the phosphatidylinositol transfer protein and phospholipase D in signal transmission, and the structures of the 1,2-diacylglycerol and calcium-binding sites of protein kinase C are discussed. Further, ceramide signaling through protein kinases and the role of cross-talk in the signaling of apoptosis and inflammation are addressed.