URINARY ELECTROLYTE EXCRETION IN 24 HOURS AND BLOOD-PRESSURE IN THE INTERSALT STUDY .1. ESTIMATES OF RELIABILITY
URINARY ELECTROLYTE EXCRETION IN 24 HOURS AND BLOOD-PRESSURE IN THE INTERSALT STUDY .1. ESTIMATES OF RELIABILITY
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DOI：
10.1093/oxfordjournals.aje.a117099
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发表时间：
1994-05-01
影响因子：
5
通讯作者：
ELLIOTT, P
中科院分区：
文献类型：
--
作者：
DYER, AR;SHIPLEY, M;ELLIOTT, P
这是两份报告中的第一份，涉及24小时尿电解质排泄和血压测量的可靠性，以及盐间电解质-血压相关性的估计，这是一项关于电解质排泄和其他因素与血压关系的国际研究，涉及来自32个国家52个中心的10,000多人。这份第一份报告描述了评估可靠性的方法，考虑了年龄和性别，并提供了几个尿液变量、血压和脉率的估计。第二份报告(Am J Epidformol 1994；139：940-51)使用这些可靠性估计和多变量程序来校正血压对24小时尿钠和钾排泄量、体重指数和酒精摄入量的回归的多元回归系数，以得出回归稀释偏差。根据重复测量的805名Intersalt参与者的数据，计算了年龄和性别调整后的可靠性估计。24小时尿钠0.37~0.40，钾0.47~0.52，钠钾比0.32~0.36，钙0.64~0.69，肌酐0.59~0.65，尿量0.49~0.57，镁0.49~0.51，脉搏0.58~0.62，收缩压0.69~0.74，舒张压0.63~0.67。此外，对电解质之间的人内和人与人之间的协方差的估计表明，在一次24小时尿液采集中观察到的钠和钾排泄的协方差中，约有一半是由于人内排泄的协方差。
This is the first of two reports dealing with the reliability of measurements of 24-hour urinary electrolyte excretion and blood pressure and estimates of electrolyte-blood pressure associations in INTERSALT, an international study of the relations of electrolyte excretion and other factors to blood pressure, involving more than 10,000 persons from 52 centers in 32 countries. This first report describes methods for estimating reliability, taking into account age and sex, and provides estimates for several urinary variables, blood pressure, and pulse rate. The second report (Am J Epidemiol 1994;139:940-51) uses these estimates of reliability and multivariate procedures to correct multiple regression coefficients from regressions of blood pressure on 24-hour urinary sodium and potassium excretion, body mass index, and alcohol intake for ''regression dilution bias.'' Age- and sex-adjusted estimates of reliability were computed from data on 805 INTERSALT participants with repeat measurements. These estimates ranged from 0.37 to 0.40 for 24-hour urinary sodium, from 0.47 to 0.52 for potassium, from 0.32 to 0.36 for the sodium:potassium ratio, from 0.64 to 0.69 for calcium, from 0.59 to 0.65 for creatinine, from 0.49 to 0.57 for urinary volume, from 0.49 to 0.51 for magnesium, from 0.58 to 0.62 for pulse, from 0.69 to 0.74 for systolic blood pressure, and from 0.63 to 0.67 for diastolic blood pressure. In addition, estimates of within- and between-person covariances among electrolytes indicated that about half of the observed covariance for sodium and potassium excretion in a single 24-hour urine collection was due to within-person covariation in excretion.