NEW ATTACHMENT FORMATION FOLLOWING CONTROLLED TISSUE REGENERATION USING BIODEGRADABLE MEMBRANES
NEW ATTACHMENT FORMATION FOLLOWING CONTROLLED TISSUE REGENERATION USING BIODEGRADABLE MEMBRANES
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DOI：
10.1902/jop.1988.59.1.1
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发表时间：
1988-01-01
影响因子：
4.3
通讯作者：
COLLINS, BR
中科院分区：
文献类型：
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作者：
MAGNUSSON, I;BATICH, C;COLLINS, BR
在狗牙周手术后的愈合过程中，本研究评估了去除牙周结缔组织和上皮后重建结缔组织附着的可能性。两只狗的颊粘骨膜瓣在所有四个前磨牙区域都升高了。24个牙根的颊骨质缩小到原来水平的25%左右。在更换和缝合凸起的皮瓣之前，调整薄膜以覆盖暴露的根面。在8个表面上使用了微孔过滤器，在8个表面上使用了可生物降解的聚乳酸薄膜。其余8个作为对照的牙根表面不放置膜。愈合两个月后，处死动物，对所有的牙根进行组织学分析。在所有被聚乳酸膜覆盖的牙根中，观察到新形成的牙骨质，并插入胶原纤维，平均覆盖初始缺损处的46%。新生骨覆盖了39%的初始缺损区。被微孔滤膜覆盖的牙根具有明显较少的新附着和骨质。在对照根中，仅在一些根的缺损处底部发现了少量的新附着。结果表明，在愈合过程中放置聚乳酸膜，以排除上皮和牙龈结缔组织，明显有利于结缔组织附着的建立。
The present study evaluated the potential for reestablishment of connective tissue attachment after exclusion of the gingival connective tissue and epithelium during healing after periodontal surgery in a dog model. Buccal mucoperiosteal flaps were elevated in all four premolar regions in two dogs. The buccal bone was reduced to approximately 25% of its original level on 24 roots. Before the elevated flaps were replaced and sutured, membranes were adjusted to cover the exposed root surfaces. On eight surfaces Millipore filters were used and on eight surfaces biodegradable polylactic acid membranes were used. No membranes were placed over the remaining eight root surfaces which served as controls. After two months of healing, the animals were sacrificed and all the roots were subjected to histological analysis. In all of the roots covered with the polylactic acid membrane, newly formed cementum with inserting collagen fibers was observed and covered on the average 46% of the initial defect. Newly formed bone covered 39% of the initial defect. The roots covered by Millipore filters were characterized by significantly less new attachment and bone. In the control roots only minor new attachment was found in the botton of the defect in some roots. The results suggest that the establishment of a connective tissue attachment is clearly favored by the placement of a polylactic acid membrane to exclude the epithelium and gingival connective tissue during healing.