Cecal adenocarcinoma with prominent rhabdoid feature: Report of a case with immunohistochemical, ultrastructural, and molecular analyses
Cecal adenocarcinoma with prominent rhabdoid feature: Report of a case with immunohistochemical, ultrastructural, and molecular analyses
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DOI：
10.1177/1066896907302418
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发表时间：
2007-10-01
影响因子：
1.2
通讯作者：
Fujimori, Takahiro
中科院分区：
文献类型：
--
作者：
Kono, Tokuyuki;Imai, Yasuo;Fujimori, Takahiro
大肠腺癌的横纹肌样表型极为罕见，只有一例腺癌显示横纹肌样去分化的报告。作者报告一例盲肠腺癌，66岁男性，肿瘤大小约13 cm，主要由横纹肌样细胞组成，部分为腺癌，并可见腺癌向横纹肌样区的过渡。超微结构分析显示胞质内聚集的中间丝的横纹肌样细胞。腺癌细胞对细胞角蛋白7和AE 1/3呈弥漫性免疫反应，但偶见波形蛋白阳性。横纹肌样细胞对细胞角蛋白7呈阴性，对AE 1/3呈弱/局灶性免疫反应，对波形蛋白呈弥漫性阳性。结果提示横纹肌样细胞为去分化腺癌。横纹肌样细胞的分子生物学分析也被提出。
Colorectal adenocarcinoma with rhabdoid phenotype is extremely rare, and only I case of adenocarcinoma showing rhabdoid dedifferentiation has been reported. The authors present another case of cecal adenocarcinoma with prominent rhabdoid feature in a 66-yearold man. The 13-cm sized tumor consisted mainly of rhabdoid cells and partly of adenocarcinoma, and transition from adenocarcinoma to rhabdoid areas was noted. Ultrastructural analysis revealed intracytoplasmic aggregates of intermediate filaments in the rhabdoid cells. Adenocarcinoma cells were diffusely immunoreactive to cytokeratin 7 and AE 1/3, but occasionally positive for vimentin. The rhabdoid cells were negative for cytokeratin 7, weakly/focally immunoreactive to AE 1/3, and diffusely positive for vimentin. These results suggested that the rhabdoid cells were dedifferentiated adenocarcinoma. Analysis of the rhabdoid cells with molecular techniques is also presented.