Association between reduced extraversion and right posterior fusiform gyrus gray matter reduction in chronic schizophrenia.
Association between reduced extraversion and right posterior fusiform gyrus gray matter reduction in chronic schizophrenia.
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DOI：
10.1176/appi.ajp.162.3.599
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发表时间：
2005-03
期刊：
影响因子：
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通讯作者：
T. Onitsuka;P. Nestor;R. Gurrera;M. Shenton;K. Kasai;Melissa Frumin;M. Niznikiewicz;R. McCarley
中科院分区：
文献类型：
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作者：
T. Onitsuka;P. Nestor;R. Gurrera;M. Shenton;K. Kasai;Melissa Frumin;M. Niznikiewicz;R. McCarley
目的探讨精神分裂症患者与面孔加工有关的梭状回体积与外倾性人格特征之间的关系。方法男性患者（N=24）和年龄匹配的男性对照受试者（N=26）完成NEO五因素量表人格外向性测量，并接受前、后梭状回灰质的高空间分辨率磁共振成像。结果：低外倾性评分与患者右侧后梭状回灰质体积减少显著相关，但与对照组无关。结论：右后梭状回体积减少可能导致疾病相关的社会障碍，其特征是外向性降低和对人脸的敏感性降低。
OBJECTIVE The authors examined the association between volume of the fusiform gyrus, a region involved in face processing, and the personality trait of extraversion in patients with schizophrenia. METHOD Male patients (N=24) and age-matched male comparison subjects (N=26) completed NEO Five-Factor Inventory personality measures of extraversion and underwent high-spatial-resolution magnetic resonance imaging of anterior and posterior fusiform gyrus gray matter. RESULTS Low extraversion scores were significantly correlated with gray matter volume reductions in the right posterior fusiform gyrus for patients but not comparison subjects. CONCLUSIONS Reduced right posterior fusiform gyrus volume may contribute to disease-related social disturbances, characterized by both low extraversion and reduced sensitivity to human faces.