Ultrasound triggered, image guided, local drug delivery
Ultrasound triggered, image guided, local drug delivery
复制标题
DOI：
10.1016/j.jconrel.2010.07.117
复制
发表时间：
2010-11-20
影响因子：
10.8
通讯作者：
Moonen, Chrit T. W.
中科院分区：
文献类型：
--
作者：
Deckers, Roel;Moonen, Chrit T. W.
超声波允许以非侵入性的方式将热能和机械能沉积在人体深处。超声波可以聚焦在直径约1 mm的区域内。超声波的生物效应可以导致局部组织加热、气穴和辐射力，可用于1）血液中循环的纳米载体的局部药物释放，2）增加药物和/或载体的渗出，3）增强药物的扩散性。当使用对机械力（振荡超声压力波）敏感和/或对温度敏感的纳米载体时，纳米载体的内容物可以局部释放。25年前，热敏脂质体已被建议用于局部药物释放与局部热疗的组合。微泡可以被专门设计为增强空化效应。实时成像方法，如磁共振，光学和超声成像，导致了新的见解和方法，超声触发的药物输送。超声的图像引导可用于：1）目标识别和表征; 2）释放或激活药物和/或透化膜的动作的时空引导; 3）生物分布、药代动力学和药效学的评估;以及4）生理学读数以评估治疗功效。(C)2010 Elsevier B. V.保留所有权利。
Ultrasound allows the deposition of thermal and mechanical energies deep inside the human body in a non-invasive way. Ultrasound can be focused within a region with a diameter of about 1 mm. The bio-effects of ultrasound can lead to local tissue heating, cavitation, and radiation force, which can be used for 1) local drug release from nanocarriers circulating in the blood, 2) increased extravasation of drugs and/or carriers, and 3) enhanced diffusivity of drugs. When using nanocarriers sensitive to mechanical forces (the oscillating ultrasound pressure waves) and/or sensitive to temperature, the content of the nanocarriers can be released locally. Thermo-sensitive liposomes have been suggested for local drug release in combination with local hyperthermia more than 25 years ago. Microbubbles may be designed specifically to enhance cavitation effects. Real-time imaging methods, such as magnetic resonance, optical and ultrasound imaging have led to novel insights and methods for ultrasound triggered drug delivery. Image guidance of ultrasound can be used for: 1) target identification and characterization; 2) spatio-temporal guidance of actions to release or activate the drugs and/or permeabilize membranes; 3) evaluation of bio-distribution, pharmacokinetics and pharmacodynamics; and 4) physiological read-outs to evaluate the therapeutic efficacy. (C) 2010 Elsevier B.V. All rights reserved.