Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration for pancreatic cancer: A meta-analysis
Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration for pancreatic cancer: A meta-analysis
复制标题
DOI：
10.1016/j.pan.2013.01.013
复制
发表时间：
2013-05-01
期刊：
影响因子：
3.6
通讯作者：
Zhang, Taiping
中科院分区：
文献类型：
--
作者：
Chen, Ge;Liu, Shanglong;Zhang, Taiping
背景与目的：EUS-FNA在许多中心已广泛应用于临床。本荟萃分析旨在研究EUS-FNA在胰腺癌中的诊断作用。方法：对EUS-FNA在胰腺癌诊断中的准确性进行综述。采用随机效应模型汇总敏感性、特异性、阳性似然比（PLR）、阴性似然比（NLR）和诊断优势比（DOR）。构建了一个汇总的接收者工作特征（SROC）来总结总体测试性能。结果：31篇文章符合meta分析。EUS-FNA诊断胰腺癌的综合敏感性、特异性、PLR、NLR、DOR分别为0.89 （95%CI: 0.88 ~ 0.90）、0.96 （95%CI: 0.95 ~ 0.97）、16.88 （95%CI: 10.63 ~ 26.79）、0.13 （95%CI: 0.10 ~ 0.16）、150.80 （95%CI: 95.94 ~ 237.03）。在前瞻性研究的亚组荟萃分析中，合并敏感性、特异性、PLR、NLR和DOR分别为0.91 （95%CI: 0.90-0.93）、0.94 （95%CI: 0.91-0.96）、11.19 （95%CI: 6.36-19.69）、0.10 （95%CI: 0.07-0.15）和125.22（62.37-251.41）。曲线下面积（AUC）为0.97，总体准确度较好。结论：EUS-FNA鉴别胰腺癌具有较高的敏感性和特异性。此外，它也是一种安全的诊断方式，并发症少。版权所有，IAP和EPC。由爱思唯尔印度出版，爱思唯尔印度有限公司的一个部门。版权所有。
Background and objective: EUS-FNA of pancreatic lesion has been put into clinical use widely in many centers. The present meta-analysis was conducted to study the diagnostic role of EUS-FNA in pancreatic cancer.Methods: A comprehensive review of study on the precision of EUS-FNA in the diagnosis of pancreatic cancer. A random effects model was used to pool the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR) and diagnostic odds ratio (DOR). A summary receiver-operating characteristic (SROC) was constructed to summarize the overall test performance.Results: Thirty-one articles were eligible for the meta-analysis. The pooled sensitivity, specificity, PLR, NLR and DOR of EUS-FNA in the diagnosis of pancreatic cancer were 0.89 (95%CI: 0.88-0.90), 0.96 (95%CI: 0.95-0.97), 16.88 (95%CI: 10.63-26.79), 0.13 (95%CI: 0.10-0.16) and 150.80 (95%CI: 95.94-237.03) respectively. In subgroup meta-analysis of the prospective studies, the pooled sensitivity, specificity, PLR, NLR and DOR were 0.91 (95%CI: 0.90-0.93), 0.94 (95%CI: 0.91-0.96), 11.19 (95%CI: 6.36-19.69), 0.10 (95%CI: 0.07-0.15) and 125.22 (62.37-251.41). The area under the curve (AUC) was 0.97, indicating a good performance of overall accuracy.Conclusion: EUS-FNA has the high sensitivity and specificity in differentiating pancreatic cancer. Moreover, it is also a safe diagnostic modality with little complications. Copyright (C) 2013, IAP and EPC. Published by Elsevier India, a division of Reed Elsevier India Pvt. Ltd. All rights reserved.