Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: implications for colon carcinogenesis.
Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: implications for colon carcinogenesis.
复制标题
胆汁酸减少丁酸钠对人结肠腺瘤 (AA/C1) 细胞的凋亡诱导作用：对结肠癌发生的影响。
DOI：
10.1006/bbrc.2000.2899
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发表时间：
2000
影响因子：
3.1
通讯作者：
Janet M Lord
中科院分区：
文献类型：
--
作者：
Lorna McMillan;S. Butcher;Yvonne Wallis;J. Neoptolemos;Janet M Lord
Butyrate is produced in the colon by fermentation of dietary fibre and induces apoptosis in colon adenoma and cancer cell lines, which may contribute to the protective effect of a high fibre diet against colorectal cancer (CRC). However, butyrate is present in the colon together with unconjugated bile acids, which are tumour promoters in the colon. We show here that bile acids deoxycholate (DCA) and chenodeoxycholate (CDCA), at levels present in the colon, gave a modest increase in cell proliferation and decreased spontaneous apoptosis in AA/C1 adenoma cells. Bile acids significantly inhibited the induction of apoptosis by butyrate in AA/C1 cells. However, the survival-inducing effects of bile acids on AA/C1 cells could be overcome by increasing the concentration of sodium butyrate. These results suggest that dysregulation of apoptosis in colonic epithelial cells by dietary factors is a key factor in the pathophysiology of CRC.
影响因子：
4.7
作者：
Mahmoud, NN;Dannenberg, AJ;Bertagnolli, MM
通讯作者：
Bertagnolli, MM
影响因子：
10.3
作者：
SANDLER, RS;LYLES, CM;KUPPER, LL
通讯作者：
KUPPER, LL