SYNAPTIC REORGANIZATION IN THE HIPPOCAMPUS INDUCED BY ABNORMAL FUNCTIONAL-ACTIVITY
SYNAPTIC REORGANIZATION IN THE HIPPOCAMPUS INDUCED BY ABNORMAL FUNCTIONAL-ACTIVITY
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DOI：
10.1126/science.2449733
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发表时间：
1988-03-04
期刊：
影响因子：
56.9
通讯作者：
SCOTT, G
中科院分区：
文献类型：
--
作者：
SUTULA, T;HE, XX;SCOTT, G
异常的功能活动诱导神经通路的长期生理改变，这可能在癫痫的发展中起作用。这些改变的细胞机制尚不清楚。一种假说认为异常活动引起神经通路的结构重组并促进癫痫发生。本报告提供的形态学证据表明，在没有明显形态学损伤的情况下，同步穿孔通路激活和边缘通路的点燃可诱导大鼠海马轴突生长和突触重组。结果表明，一种以前未被认识到的解剖学可塑性与神经通路中癫痫发作的同步活动和发展有关。
Abnormal functional activity induces long-lasting physiological alterations in neural pathways that may play a role in the development of epilepsy. The cellular mechanisms of these alterations are not well understood. One hypothesis is that abnormal activity causes structural reorganization of neural pathways and promotes epileptogenesis. This report provides morphological evidence that synchronous perforant path activation and kindling of limbic pathways induce axonal growth and synaptic reorganization in the rat hippocampus, in the absence of overt morphological damage. The results show a previously unrecognized anatomic plasticity associated with synchronous activity and development of epileptic seizures in neural pathways.