Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
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DOI：
10.1038/s41598-020-59373-w
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发表时间：
2020-02-17
影响因子：
4.6
通讯作者：
Garcia de Viedma, Dario
中科院分区：
文献类型：
--
作者：
Abascal, Estefania;Herranz, Marta;Garcia de Viedma, Dario
评估监狱中的耐多药结核病及其对该疾病全球流行病学的影响是相关的。然而，缺乏监狱中系统的分子流行病学计划。对从秘鲁监狱转移到西班牙的囚犯进行的一项健康检查计划导致拉丁美洲最大的监狱之一诊断出五例耐多药结核病病例。它们分为两个MIRU-VNTR簇（卡劳-1和卡劳-2），表明两种流行MDR菌株的储存库。推断出高的过度表达率是因为5例病例中有1例同时感染了泛敏感菌株。2018年，在西班牙的一个社区病例中也发现了卡劳-1菌株，该病例曾于2002-5年在同一秘鲁监狱服刑。在秘鲁实施了根据WGS数据量身定制的菌株特异性PCR，从而确认这些菌株目前是该监狱中大多数MDR病例的原因，包括新的混合感染。
It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR-clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002-5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.