A pilot study of changes in functional brain activity during a working memory task after mSMT treatment: The MEMREHAB trial.
A pilot study of changes in functional brain activity during a working memory task after mSMT treatment: The MEMREHAB trial.
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DOI：
10.1016/j.msard.2016.03.012
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发表时间：
2016-05
影响因子：
4
通讯作者：
Chiaravalloti ND
中科院分区：
文献类型：
--
作者：
Huiskamp M;Dobryakova E;Wylie GD;DeLuca J;Chiaravalloti ND
工作记忆缺陷在多发性硬化症（MS）中很常见。改进的故事记忆技巧（mSMT）已被证明可以改善MS的新学习和记忆，但其对工作记忆（WM）的影响目前尚不清楚。本研究对一项大型双盲、安慰剂对照、随机临床试验的数据进行了二次分析，并检查了mSMT治疗后WM任务中大脑激活的变化。16名临床明确的多发性硬化症患者被随机分配到治疗组（n = 7）或安慰剂对照组（n = 9），根据性别、年龄和教育程度进行匹配。对所有受试者进行基线和即时随访的功能性磁共振成像（fMRI）检查。在fMRI期间，参与者完成了N-back任务，包括0- back、1- back和2-back条件。在随访中，治疗组的背外侧前额叶皮层、辅助运动区和顶叶下小叶的大脑活动明显增加。安慰剂对照组没有明显的变化。由于样本量小，本研究的结果应被解释为初步的。然而，在治疗组中观察到的与WM相关的额顶叶网络的激活模式表明，mSMT训练增加了注意力和WM相关神经网络的招募。我们得出结论，mSMT治疗导致wm相关大脑激活的改变。
Working memory deficits are common in multiple sclerosis (MS). The modified Story Memory Technique (mSMT) has been shown to improve new learning and memory in MS, but its effects on working memory (WM) are currently unknown. The present study presents a secondary analysis of data from a larger double-blind, placebo-controlled, randomized clinical trial and examines changes in cerebral activation on a WM task following mSMT treatment. Sixteen participants with clinically definite MS were randomly assigned to treatment (n = 7) or placebo-control groups (n = 9) matched for gender, age and education. Baseline and immediate follow-up functional Magnetic Resonance Imaging (fMRI) was obtained for all subjects. During fMRI participants completed an N-back task, consisting of 0-, 1- and 2-back conditions. Significant increases in cerebral activation were noted in the dorsolateral prefrontal cortex, supplementary motor area and inferior parietal lobule at follow-up in the treatment group. No significant changes were noted in the placebo control group. Due to the small sample size, results of the current study should be interpreted as preliminary. However, the observed pattern of activation of the frontoparietal network involved in WM found in the treatment group, suggests that mSMT training increases recruitment of attention- and WM-related neural networks. We conclude that mSMT treatment leads to changes in WM-related cerebral activation.