Associations between metabolic disorders and risk of cancer in Danish men and women--a nationwide cohort study.
Associations between metabolic disorders and risk of cancer in Danish men and women--a nationwide cohort study.
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DOI：
10.1186/s12885-016-2122-7
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发表时间：
2016-02-22
期刊：
影响因子：
3.8
通讯作者：
Schmiegelow MD
中科院分区：
文献类型：
--
作者：
Berger SM;Gislason G;Moore LL;Andersson C;Torp-Pedersen C;Denis GV;Schmiegelow MD
代谢紊乱的患病率正在增加，并被认为会增加癌症风险，但代谢紊乱与癌症风险之间的关系尚不清楚，特别是在年轻人中。我们调查了糖尿病、高血压和高胆固醇血症与所有部位以及特定部位癌症风险之间的关系。我们连续纳入了1996-2011年丹麦全国登记处的男性和女性，如果年龄在20-89岁之间，并且在进入日期之前没有癌症。我们在2012年一直在跟踪他们。使用出院诊断代码和声明的处方定义代谢紊乱。我们使用时间依赖性性别分层泊松回归模型，根据年龄和日历年进行调整，以评估代谢紊乱与所有部位和部位特异性癌症风险之间的相关性（无代谢紊乱作为参考）。在平均12.6（±5.7标准差[SD]）年的随访期间，4，826，142名平均年龄为41.4（±18.9 SD）岁的个体（50.2%为女性）发生了423，942例癌症事件。糖尿病或高血压患者在诊断为代谢紊乱后即刻的全部位癌症发病率比（IRR）最高。在女性中，与糖尿病相关的癌症风险继续下降，尽管仍然显着（诊断后1-8年的IRR为1.18-1.22）。对于男性糖尿病和高血压，IRR稳定并在约一年后保持显著增加，男性糖尿病的IRR为1.10-1.13，两性高血压的IRR为1.07-1.14。相反，高胆固醇血症（他汀类药物治疗）和癌症风险之间没有观察到相关性。高血压和癌症风险之间的关联在20-34岁的年轻人中最强，并随着年龄的增长而下降。糖尿病和高血压与全身性癌症的风险增加有关。本文的在线版本（doi：10.1186/s12885-016-2122-7）包含补充材料，可供授权用户使用。
The prevalence of metabolic disorders is increasing and has been suggested to increase cancer risk, but the relation between metabolic disorders and risk of cancer is unclear, especially in young adults. We investigated the associations between diabetes, hypertension, and hypercholesterolemia on risk of all-site as well as site-specific cancers. We consecutively included men and women from nationwide Danish registries 1996–2011, if age 20–89 and without cancer prior to date of entry. We followed them throughout 2012. Metabolic disorders were defined using discharge diagnosis codes and claimed prescriptions. We used time-dependent sex-stratified Poisson regression models adjusted for age and calendar year to assess associations between metabolic disorders, and risk of all-site and site-specific cancer (no metabolic disorders as reference). Over a mean follow-up of 12.6 (±5.7 standard deviations [SD]) years, 4,826,142 individuals (50.2 % women) with a mean age of 41.4 (±18.9 SD) years had 423,942 incident cancers. Incidence rate ratios (IRRs) of all-site cancer in patients with diabetes or hypertension were highest immediately following diagnosis of metabolic disorder. In women, cancer risk associated with diabetes continued to decline albeit remained significant (IRRs of 1.18–1.22 in years 1–8 following diagnosis). For diabetes in men, and hypertension, IRRs stabilized and remained significantly increased after about one year with IRRs of 1.10-1.13 in men for diabetes, and 1.07–1.14 for hypertension in both sexes. Conversely, no association was observed between hypercholesterolemia (treatment with statins) and cancer risk. The association between hypertension and cancer risk was strongest in young adults aged 20–34 and decreased with advancing age. Diabetes and hypertension were associated with increased risk of all-site cancer. The online version of this article (doi:10.1186/s12885-016-2122-7) contains supplementary material, which is available to authorized users.