Medullary thyroid cancer: the Functions of raf-1 and human achaete-scute homologue-1

Medullary thyroid cancer: the Functions of raf-1 and human achaete-scute homologue-1
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DOI:
10.1089/thy.2005.15.511
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发表时间:
2005-06-01
期刊:
影响因子:
6.6
通讯作者:
Van Gompel, JJ
Van Gompel, JJ
中科院分区:
医学1区
文献类型:
--
作者:
Chen, H;Kunnimalaiyaan, M;Van Gompel, JJ

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甲状腺髓样癌(MTC)是甲状腺C细胞的原型神经内分泌肿瘤。除了手术,没有治疗MTC的治疗方法。在这篇综述中,我们详细介绍了最近的研究表明,针对特定的信号通路可能是一个可行的策略,以控制MTC肿瘤的进展。具体而言,我们讨论了raf-1和无壳-scute同源物-1途径在MTC肿瘤生长和分化中的作用。
Medullary thyroid cancer (MTC) is a prototypic neuroendocrine tumor of the thyroid C cells. Other than surgery, there are no curative therapies for MTC. In this review, we detail recent studies that suggest that targeting specific signaling pathways may be a viable strategy to control MTC tumor progression. Specifically, we discuss the role of the raf-1 and achaete-scute homologue-1 pathways in the MTC tumor growth and differentiation.