Rapid compression transforms interfacial monolayers of pulmonary surfactant
Rapid compression transforms interfacial monolayers of pulmonary surfactant
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DOI：
10.1016/s0006-3495(01)76156-5
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发表时间：
2001-04-01
影响因子：
3.4
通讯作者：
Hall, SB
中科院分区：
文献类型：
--
作者：
Crane, JM;Hall, SB
肺中的肺表面活性剂膜在远高于45 mN/m的平衡扩散压力的表面压力下是亚稳定的，但当在体外压缩时通常在该压力下塌陷。本文报告的研究确定了压缩率对含有37 ℃下提取的小牛表面活性剂的单层在捕获气泡的连续界面上保持非常高的表面压力的能力的影响。将速率从2埃（2）/磷脂/分钟（即，3%（初始面积为40 mN/m）/min）至23%/s仅产生瞬时增加至48 mN/m。然而，在32%/s的阈值速率以上，表面压力达到>68 mN/m。快速压缩后，静态膜在这些最大值和膨胀后的较低压力下均将表面压力维持在+/-1 mN/m以内
Films of pulmonary surfactant in the lung are metastable at surface pressures well above the equilibrium spreading pressure of 45 mN/m but commonly collapse at that pressure when compressed in vitro. The studies reported here determined the effect of compression rate on the ability of monolayers containing extracted calf surfactant at 37 degreesC to maintain very high surface pressures on the continuous interface of a captive bubble. Increasing the rate from 2 Angstrom (2)/phospholipid/min (i.e., 3% of (initial area at 40 mN/m)/min) to 23%/s produced only transient increases to 48 mN/m. Above a threshold rate of 32%/s, however, surface pressures reached >68 mN/m. After the rapid compression, static films maintained surface pressures within +/-1 mN/m both at these maximum values and at lower pressures following expansion at