Assembly and biological role of podosomes and invadopodia
Assembly and biological role of podosomes and invadopodia
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DOI：
10.1016/j.ceb.2008.01.005
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发表时间：
2008-04-01
影响因子：
7.5
通讯作者：
Linder, Stefan
中科院分区：
文献类型：
--
作者：
Gimona, Mario;Buccione, Roberto;Linder, Stefan
通过运动和裂解事件进行的受调控的组织侵袭对于诸如免疫系统功能、炎症反应、伤口愈合以及器官发育等生理过程至关重要，但这一过程的病理性破坏会驱动肿瘤细胞的侵袭和转移。细胞迁移和侵袭需要整合几个过程，包括：第一，细胞骨架结构和收缩力的局部调节；第二，底物黏附及其相关微丝的周转；第三，产生介导细胞外基质依赖蛋白酶的局部降解的特殊的瞬时结构域。近期的研究重新发现了显著的基于肌动蛋白的细胞结构，称为侵袭足体和足小体，它们是独特的结构和功能模块，主要的侵袭机制通过它们受到调控。现在已到了揭示它们在组织可塑性和修复的生理学及病理学中所起作用的时候了。
Regulated tissue invasion via motile and lytic events is critical for physiological processes such as immune system function and inflammatory responses, wound healing, and organ development, but pathological subversion of this process drives tumour cell invasion and metastasis. Cell migration and invasion require the integration of several processes that include: first, the local modulation of cytoskeleton structure and contractile forces; second, the turnover of substrate adhesions and their associated microfilaments; and third, the generation of specialised, transient domains that mediate the protease-dependent focal degradation of the extracellular matrix. Recent work has re-discovered prominent actin-based cellular structures, termed invaclopodia and podosomes, as unique structural and functional modules through which major invasive mechanisms are regulated. The stage is now set to unravel their roles in the physiology and pathology of tissue plasticity and repair.