Calretinin: Modulator of neuronal excitability
Calretinin: Modulator of neuronal excitability
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DOI：
10.1016/j.biocel.2009.05.007
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发表时间：
2009-11-01
影响因子：
4
通讯作者：
Wijesinghe, Rajiv
中科院分区：
文献类型：
--
作者：
Camp, Aaron James;Wijesinghe, Rajiv
钙视网膜蛋白是钙结合蛋白EF-hand家族的一员，首先在视网膜中发现。与其他200多种钙结合蛋白一样。钙视网膜蛋白发挥一系列细胞功能，包括细胞内钙缓冲、信使靶向，并参与诸如细胞周期停滞和细胞凋亡的过程。钙结合蛋白（calretinin）在脊椎动物和无脊椎动物神经系统的神经元亚群中表达差异，其表达已被用于选择性靶向特定细胞类型和分离神经元网络。最近的实验表明，calretinin在调节神经元的内在兴奋性和诱导长时程增强（LTP）中起着至关重要的作用。此外，在小鼠中选择性敲除钙视网膜蛋白产生运动协调障碍，并表明钙视网膜蛋白在维持运动适应的钙动力学中的假定作用。(C)2009爱思唯尔有限公司保留所有权利。
Calretinin is a member of the calcium-binding protein EF-hand family first identified in the retina. As with the other 200-plus calcium-binding proteins. calretinin serves a range of cellular functions including intracellular calcium buffering, messenger targeting, and is involved in processes such as cell cycle arrest, and apoptosis. Calcium-binding proteins including calretinin are expressed differentially in neuronal subpopulations throughout the vertebrate and invertebrate nervous system and their expression has been used to selectively target specific cell types and isolate neuronal networks More recent experiments have revealed that calretinin plays a crucial role in the modulation of intrinsic neuronal excitability and the induction of long-term potentiation (LTP). Furthermore, selective knockout of calretinin in mice produces disturbances of motor coordination and suggests a putative role for calretinin in the maintenance of calcium dynamics underlying motor adaptation. (C) 2009 Elsevier Ltd. All rights reserved.