Soluble UL16-binding protein 2 is associated with a poor prognosis in pancreatic cancer patients
Soluble UL16-binding protein 2 is associated with a poor prognosis in pancreatic cancer patients
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DOI：
10.1016/j.bbrc.2019.07.020
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发表时间：
2019-09-10
影响因子：
3.1
通讯作者：
Takehara, Tetsuo
中科院分区：
文献类型：
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作者：
Kegasawa, Tadashi;Tatsumi, Tomohide;Takehara, Tetsuo
免疫系统在胰腺癌中起着重要作用。MHC I类链相关蛋白A和B（云母/B）和UL 16结合蛋白（ULBP）是已知的自然杀伤组2D（NKG 2D）配体。可溶性NKG 2D配体可抑制自然杀伤（NK）细胞的活化。在胰腺癌中，与可溶性云母/B相比，可溶性ULBP相对未被研究。我们研究了可溶性ULBP，特别是ULBP 2在胰腺癌中的意义。在胰腺癌细胞培养上清中检测到可溶性ULBP 2，但未检测到可溶性ULBP 1和可溶性ULBP 3。胰腺癌细胞来源的可溶性ULBP 2可降低NK细胞的细胞毒活性。多变量分析表明，血清可溶性ULBP 2是所有胰腺癌患者（特别是IV期患者）总生存期（OS）较差的重要独立因素。结论：胰腺癌源性可溶性ULBP 2可能影响胰腺癌的预后。(C)2019爱思唯尔公司All rights reserved.
The immune system plays important roles in pancreatic cancer. MHC class I-chain-related proteins A and B (MICA/B) and UL16-binding proteins (ULBPs) are known natural killer group 2D (NKG2D) ligands. Soluble NKG2D ligands can inhibit the activation of Natural killer (NK) cells. In pancreatic cancer, soluble ULBPs are relatively unstudied in contrast to soluble MICA/B. We examined the significance of soluble ULBPs, especially ULBP2, in pancreatic cancer. Soluble ULBP2 but neither soluble ULBP1 nor soluble ULBP3, was etected in the supernatants of pancreatic cancer cells. Soluble ULBP2 derived from pancreatic cancer cells could reduce the cytotoxicity of NK cells. Multivariate analysis demonstrated that serum soluble ULBP2 was a significant independent factor associated with poor overall survival (OS) in all pancreatic cancer patients, specifically in stage IV patients. In conclusion, pancreatic cancer-derived soluble ULBP2 might affect the prognosis in pancreatic cancer. (C) 2019 Elsevier Inc. All rights reserved.