Comparative performance study of different sample introduction techniques for rapid and precise selenium isotope ratio determination using multi-collector inductively coupled plasma mass spectrometry (MC-ICP/MS)
Comparative performance study of different sample introduction techniques for rapid and precise selenium isotope ratio determination using multi-collector inductively coupled plasma mass spectrometry (MC-ICP/MS)
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DOI：
10.1007/s00216-007-1537-z
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发表时间：
2007-11-01
影响因子：
4.3
通讯作者：
Hintelmann, Holger
中科院分区：
文献类型：
--
作者：
Elwaer, Nagmeddin;Hintelmann, Holger
采用多收集器电感耦合等离子体质谱法（MC-ICP/MS）测定硒同位素比，比较了5种进样系统、交叉流雾化器喷雾室、两种不同溶剂脱溶系统、多模式进样系统（MSIS）和氢化物生成系统（LI2）的分析性能。确定了每次样品导入获得最高Se信噪比（S/N）和同位素比精度的最佳操作参数。氢化物生成（LI2）体系被认为是最合适的样品导入方法，对硒同位素比测量具有最大的灵敏度和精度。与MSIS相比，它提供了5倍于MSIS的所有Se同位素的S/N比，20倍于两个脱溶单元的S/N比，100倍于传统喷雾室样品导入方法产生的S/N比。在100 ng mL(-1) Se下，使用喷雾室、两次溶解、MSIS和LI2系统耦合到MC-ICP/MS时，Se-78/Se-82比的内部精度分别为150、125、114、13和7 ppm。仪器：用指数法修正函数计算质量偏差因子(K)。在5种样品导入体系中，LI2的质量偏差最小，为-0.0265，脱溶体系的质量偏差最大，为-0.0321。
The analytical performance of five sample introduction systems, a cross flow nebulizer spray chamber, two different solvent desolvation systems, a multi-mode sample introduction system (MSIS), and a hydride generation (LI2) system were compared for the determination of Se isotope ratio measurements using multi-collector inductively coupled plasma mass spectrometry (MC-ICP/MS). The optimal operating parameters for obtaining the highest Se signal-to-noise (S/N) ratios and isotope ratio precision for each sample introduction were determined. The hydride generation (LI2) system was identified as the most suitable sample introduction method yielding maximum sensitivity and precision for Se isotope ratio measurement. It provided five times higher S/N ratios for all Se isotopes compared to the MSIS, 20 times the S/N ratios of both desolvation units, and 100 times the S/N ratios produced by the conventional spray chamber sample introduction method. The internal precision achieved for the Se-78/Se-82 ratio at 100 ng mL(-1) Se with the spray chamber, two desolvation, MSIS, and the LI2 systems coupled to MC-ICP/MS was 150, 125, 114, 13, and 7 ppm, respectively. Instrument: mass bias factors (K) were calculated using an exponential law correction function. Among the five studied sample introduction systems the LI2 showed the lowest mass bias of -0.0265 and the desolvation system showed the largest bias with -0.0321.