ASSESSMENT OF ACCURACY OF PET UTILIZING A 3-D PHANTOM TO SIMULATE THE ACTIVITY DISTRIBUTION OF [18F]FLUORODEOXYGLUCOSE UPTAKE IN THE HUMAN BRAIN
ASSESSMENT OF ACCURACY OF PET UTILIZING A 3-D PHANTOM TO SIMULATE THE ACTIVITY DISTRIBUTION OF [18F]FLUORODEOXYGLUCOSE UPTAKE IN THE HUMAN BRAIN
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DOI：
10.1038/jcbfm.1991.32
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发表时间：
1991-03-01
影响因子：
6.3
通讯作者：
MAZZIOTTA, JC
中科院分区：
文献类型：
--
作者：
HOFFMAN, EJ;CUTLER, PD;MAZZIOTTA, JC
三维大脑模型已被开发出来，用于模拟目前正电子发射断层扫描（PET）中使用的人脑研究中发现的活动分布。 该体模具有单个连续室，并利用透明树脂薄层分别为灰质、白质和脑脊液结构提供 5、1 和 0 的表观相对浓度。 体模和理想图像集是根据同一组数据创建的。 因此，用户可以将测量的图像与理想的图像进行比较，从而可以对 PET 研究中的错误进行定量评估，其活动分布与患者中发现的相似。 该模型用于研究死区时间和散射对当前 PET 系统定量准确度的影响。 在临床研究中发现，死区时间校正因子在计数率方面具有显着性 (1.1-2.5)。 研究发现死区时间校正技术的精确度在 5% 以内。 发射和衰减校正数据中的散射始终导致定量中出现 5-15% 的误差，而两种类型数据中的散射校正将准确度误差降低至 < 5%。
A three-dimensional brain phantom has been developed to simulate the activity distributions found in human brain studies currently employed in positron emission tomography (PET). The phantom has a single contiguous chamber and utilizes thin layers of lucite to provide apparent relative concentrations of 5, 1, and 0 for gray matter, white matter, and CSF structures, respectively. The phantom and an ideal image set were created from the same set of data. Thus, the user has a basis for comparing measured images with an ideal set that allows a quantitative evaluation of errors in PET studies with an activity distribution similar to that found in patients. The phantom was employed in a study of the effect of deadtime and scatter on accuracy in quantitation on a current PET system. Deadtime correction factors were found to be significant (1.1-2.5) at count rates found in clinical studies. Deadtime correction techniques were found to be accurate to within 5%. Scatter in emission and attenuation correction data consistently caused 5-15% errors in quantitation, whereas correction for scatter in both types of data reduced errors in accuracy to < 5%.