Possible impact of neutrophils on immune responses during early pregnancy in ruminants.
Possible impact of neutrophils on immune responses during early pregnancy in ruminants.
复制标题
反刍动物怀孕早期怀孕期间的中性粒细胞可能影响。
DOI：
10.1590/1984-3143-ar2021-0048
复制
发表时间：
2021
影响因子：
1.7
通讯作者：
Antoniazzi AQ
中科院分区：
文献类型：
--
作者：
Fiorenza MF;Amaral CDS;da Anunciação ARA;Portela VVM;Marey MA;Miyamoto A;Antoniazzi AQ
早期胚胎和母体免疫系统之间的相互作用对妊娠的建立是几项研究的重点;然而，它仍然不清楚。母体免疫反应需要在避免对孕体的任何损害和维持其对抗微生物的功能之间保持平衡。当孕体-母体相互作用不能达到这种平衡时，可能会发生妊娠丢失。母亲和胎儿之间的相互沟通在妊娠早期是决定妊娠结局的基础。在反刍动物中，胚胎主要通过释放干扰素tau（IFNT）与母体系统反应。IFNT可以局部作用于胚胎和子宫内膜细胞，并通过干扰素刺激基因（ISG）的表达在多种组织和细胞中系统地调节它们的反应。IFNT还可诱导免疫细胞中炎症相关基因的表达。第7天胚胎诱导母体免疫应答向抗炎（Th 2）免疫应答转变。在母体识别妊娠期间，外周血单个核细胞（PBMC）和多形核细胞（PMN）表达构成抗炎反应的标志物。但PMNs的反应对IFNT的作用更为敏感。中性粒细胞更可能表达干扰素刺激基因（ISG）、转化生长因子β（TGFB）、白细胞介素10（IL 10）和白细胞介素-1（ARG 1），构成对早期妊娠最快速的免疫反应之一。本文就反刍动物妊娠早期的局部和外周免疫反应，主要是中性粒细胞在免疫系统中的作用作一综述。
The interaction between early embryo and maternal immune system for the establishment of pregnancy is the focus of several studies; however, it remains unclear. The maternal immune response needs to keep a balance between avoiding any damage to the conceptus and maintaining its function in combating microbes as well. When conceptus-maternal crosstalk cannot achieve this balance, pregnancy losses might occur. Intercommunication between mother and conceptus is fundamental during early pregnancy to dictate the outcome of pregnancy. In ruminants, the embryo reacts with the maternal system mainly via interferon tau (IFNT) release. IFNT can act locally on the embryo and endometrial cells and systemically in several tissues and cells to regulate their response via the expression of interferon-stimulated genes (ISGs). Also, IFNT can induce the expression of inflammatory-related genes in immune cells. Day 7 embryo induces a shift in the maternal immune response towards anti-inflammatory (Th2) immune responses. During maternal recognition of pregnancy, peripheral mononuclear cells (PBMCs) and polymorphonuclear cells (PMNs) express markers that configure an anti-inflammatory response. However, PMNs response is more sensitive to the effects of IFNT. PMNs are more likely to express interferon-stimulated genes (ISGs), transforming growth factor-beta (TGFB), interleukin 10 (IL10), and arginase-1 (ARG1), configuring one of the most rapid immune responses to early pregnancy. This review focus on the local and peripheral immune responses during early pregnancy in ruminants, mainly the PMNs function in the immune system.