Racial differences in breast cancer survival: The effect of residual disease
Racial differences in breast cancer survival: The effect of residual disease
复制标题
DOI：
10.1006/jsre.2001.6232
复制
发表时间：
2001-10-01
影响因子：
2.2
通讯作者：
Klimberg, VS
中科院分区：
文献类型：
--
作者：
Mancino, AT;Rubio, IT;Klimberg, VS
背景。大量研究发现非裔美国人 (AA) 和白种人 (C) 乳腺癌女性的生存率存在差异。本研究的目的是阐明我们人群中 AA 型和 C 型乳腺癌女性患者特征和结果的差异。方法。我们对 1980 年 10 月至 1998 年 12 月期间进入我们的肿瘤登记处的 1345 名新诊断乳腺癌女性进行了回顾性分析。结果。种族和就诊时的分期之间存在显着相关性，C 型和 AA 女性之间的总体中位生存期差异也很显着。数据显示，患有 I 期或 II 期疾病的 C 型和 AA 女性的生存率没有显着差异。然而，患有 III 期和 IV 期疾病的 AA 和 C 女性的中位生存时间差异非常显着。与 C 女性相比，初次治疗后 AA 女性“无病”的比例明显较低（P < 0.001）。有趣的是，当数据按阶段分层时，只有在第三阶段和第四阶段，各种族之间的无病状态才存在显着差异。结论。与 C 女性相比，AA 女性往往出现较晚，并且晚期疾病的生存率较差。患有晚期疾病的 AA 女性生存率较差似乎与达到无病状态的能力下降有关。治疗结果差异的根本原因需要进一步评估。 (C) 2001 年学术出版社。
Background. A survival difference has been seen in numerous studies between African-American (AA) and Caucasian (C) women with breast cancer. The purpose of this study was to elucidate the differences in patient characteristics and outcomes between AA and C women with breast cancer in our population.Methods. We performed a retrospective analysis of 1345 women with newly diagnosed breast cancer who were entered into our tumor registry from October 1980 to December 1998.Results. The association between race and stage at presentation was significant, as was the difference in the overall median survival between C and AA women. The data revealed no significant differences in survival between C and AA women presenting with Stage I or II disease. However, the differences between the median survival times for AA and C women presenting with Stage III and IV disease were both highly significant. A significantly lower percentage of AA women became "disease free" after initial therapy as compared with C women (P < 0.001). Interestingly, when data were stratified by stage, only in Stage III and IV were there significant differences between the races for becoming disease free.Conclusions. AA women tend to present at a later stage and have poorer survival from later-stage disease as compared with C women. The poorer survival appears to be related to the decreased ability to achieve disease-free status in AA women with advanced disease. The underlying causes of this difference in treatment outcome need further evaluation. (C) 2001 Academic Press.