Palladium(II)-catalyzed direct regioselectively oxidative acylation of azobenzenes with toluene derivatives.
Palladium(II)-catalyzed direct regioselectively oxidative acylation of azobenzenes with toluene derivatives.
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DOI：
10.1021/jo5000219
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发表时间：
2014-03
期刊：
影响因子：
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通讯作者：
H. Song;Dong Chen;C. Pi;Xiuling Cui;Yangjie Wu
中科院分区：
文献类型：
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作者：
H. Song;Dong Chen;C. Pi;Xiuling Cui;Yangjie Wu
以甲苯为原料，采用钯催化氧化活化C-H键的方法合成了一种高效、实用的酰基偶氮苯。对于33个实施例，以中等至优异的产率同时得到各种单酰基偶氮苯和二酰基偶氮苯。甲苯及其衍生物是潜在的理想酰化试剂。单酰化产物和双酰化产物可以通过氧化剂负载量来控制。
A highly efficient and practical procedure to acylazobenzene via Pd-catalyzed oxidative C-H bond activation from toluene has been developed. Various mono- and diacylazobenzene were afforded simultaneously in moderate to excellent yields for 33 examples. Toluene and its derivatives were served as potential and ideal acylation reagents. The mono- and diacylated products could be controlled by the oxidant loading.