The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord
The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord
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DOI：
10.1016/s0896-6273(01)00341-5
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发表时间：
2001-07-19
期刊：
影响因子：
16.2
通讯作者：
Anderson, DJ
中科院分区：
文献类型：
--
作者：
Chen, ZF;Rebelo, S;Anderson, DJ
检测有害刺激的皮肤感觉神经元投射到脊髓的背角，而支配肌肉拉伸受体的神经投射到腹角。DRG11是一种配对同源结构域转录因子，在发育中的背角和感觉神经元中均有表达，但在脊髓腹侧不表达。缺乏DRG11的小鼠胚胎在皮肤感觉传入纤维投射到背侧的时空模式上出现异常，但在脊髓腹侧没有异常，以及背角形态发生缺陷。这些早期发育异常导致成年人对有害刺激的敏感性显著减弱。相反，运动和感觉运动功能正常。因此，Drg11是形成从伤害性感觉神经元到脊髓背角中心目标的时空适当投射所必需的。
Cutaneous sensory neurons that detect noxious stimuli project to the dorsal horn of the spinal cord, while those innervating muscle stretch receptors project to the ventral horn. DRG11, a paired homeodomain transcription factor, is expressed in both the developing dorsal horn and in sensory neurons, but not in the ventral spinal cord. Mouse embryos deficient in DRG11 display abnormalities in the spatio-temporal patterning of cutaneous sensory afferent fiber projections to the dorsal, but not the ventral spinal cord, as well as defects in dorsal horn morphogenesis. These early developmental abnormalities lead, in adults, to significantly attenuated sensitivity to noxious stimuli. In contrast, locomotion and sensori-motor functions appear normal. Drg11 is thus required for the formation of spatio-temporally appropriate projections from nociceptive sensory neurons to their central targets in the dorsal horn of the spinal cord.