In vitro synthesis of IgG and antibodies to AChR by peripheral and thymic lymphocytes.
In vitro synthesis of IgG and antibodies to AChR by peripheral and thymic lymphocytes.
复制标题
外周血和胸腺淋巴细胞体外合成 IgG 和 AChR 抗体。
DOI：
10.1111/j.1749-6632.1987.tb51281.x
复制
发表时间：
1987
影响因子：
5.2
通讯作者：
Kornstein,MJ
中科院分区：
文献类型：
--
作者：
Lisak,RP;Levinson,AI;Zweiman,B;Kornstein,MJ
获得性重症肌无力患者的虚弱是由针对乙酰胆碱烟碱受体的自身抗体引发的神经肌肉接头处的几种免疫病理学机制造成的。4 重症肌无力患者中出现乙酰胆碱受体抗体（抗 AChR）和其他自身抗体的机制尚不清楚？ V6 我们和其他人一直对使用来自几个免疫区室的淋巴细胞的体外培养物来研究可能对控制 MG 患者的抗 AChR 和免疫球蛋白合成非常重要的细胞相互作用感兴趣。我们想回顾一下利用 MG 患者血液和胸腺细胞悬液体外合成 IgG 和抗 AChR 的研究。我们将尝试在其他人的工作背景下解释这些研究。
Weakness in patients with acquired myasthenia gravis results from several immunopathologic mechanisms at the neuromuscular junction initiated by autoantibodies directed against the nicotinic receptor for acetylcholine.'4 The mechanisms responsible for the emergence of antibodies to acetylcholine receptor (anti-AChR) and other autoantibodies in patients with myasthenia gravis are not understood? V6 We and others have been interested in using in vitro cultures of lymphocytes from several immune compartments to study cellular interactions that might be iplportant in the control of anti-AChR and immunoglobulin synthesis in patients with MG. We would like to review our studies of in vitro synthesis of IgG and anti-AChR by cell suspensions from blood and thymus of patients with MG. We will try to interpret these studies in the context of work by others.