Organ Impairment-Drug-Drug Interaction Database: A Tool for Evaluating the Impact of Renal or Hepatic Impairment and Pharmacologic Inhibition on the Systemic Exposure of Drugs.
Organ Impairment-Drug-Drug Interaction Database: A Tool for Evaluating the Impact of Renal or Hepatic Impairment and Pharmacologic Inhibition on the Systemic Exposure of Drugs.
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DOI：
10.1002/psp4.55
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Huang SM
中科院分区：
文献类型：
--
作者：
Yeung CK;Yoshida K;Kusama M;Zhang H;Ragueneau-Majlessi I;Argon S;Li L;Chang P;Le CD;Zhao P;Zhang L;Sugiyama Y;Huang SM
器官损伤和药物相互作用（OI-DDI）数据库是第一个严格组装的数据库，包含来自公开肾损伤和肝损伤研究的药代动力学药物暴露数据，以及来自药物相互作用抑制研究的药物暴露最大变化。该数据库用于系统比较肾/肝损害和药理学抑制对药物暴露的影响。随着这一数据库的公开提供，其他应用也是可行的。
The organ impairment and drug–drug interaction (OI-DDI) database is the first rigorously assembled database of pharmacokinetic drug exposure data from publicly available renal and hepatic impairment studies presented together with the maximum change in drug exposure from drug interaction inhibition studies. The database was used to conduct a systematic comparison of the effect of renal/hepatic impairment and pharmacologic inhibition on drug exposure. Additional applications are feasible with the public availability of this database.