2-Methylthio-N7-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture
2-Methylthio-N7-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture
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2-甲硫基-N7-甲基-顺式玉米素，一种从链霉菌培养物中分离出来的新型抗疟天然产物
DOI：
10.1093/bbb/zbab192
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Osada Hiroyuki
中科院分区：
文献类型：
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作者：
Lopez Julius Adam V;Nogawa Toshihiko;Yoshida Kazuko;Futamura Yushi;Osada Hiroyuki
从streptomyessp培养液中分离到2-甲基硫代- n7 -甲基顺式玉米蛋白(1)。80H647以及2个已知的嘌呤衍生物，5 ' -甲基硫代肌苷(2)和AT-265 （dealanylascamycin,3）。化合物1的结构通过高分辨率质谱（HRMS）和核磁共振（NMR）分析完成。对恶性疟原虫3d7的生长有抑制作用，gi50为2.4µm，对拟南芥2µm的生长无影响。这是首次报道从链霉属植物中提取的ann7甲基化玉米蛋白型天然产物作为抗疟疾化合物。
2-Methylthio-N7-methyl-cis-zeatin (1) was isolated from the culture broth ofStreptomycessp. 80H647 along with 2 known purine derivatives, 5′-methylthioinosine (2) and AT-265 (dealanylascamycin,3). The structure elucidation of compound1was accomplished by high-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) analyses. It inhibited the growth ofPlasmodium falciparum3D7 with a GI50of 2.4 µmand had no effect on the growth ofArabidopsisat 2 µm. This is the first report of anN7-methylated zeatin-type natural product fromStreptomycesand as an antimalarial compound.