Filling of high aspect ratio micro features of a microfluidic flow cytometer chip using micro injection moulding
Filling of high aspect ratio micro features of a microfluidic flow cytometer chip using micro injection moulding
复制标题
使用微注射成型填充微流控流式细胞仪芯片的高纵横比微特征
DOI：
10.1088/1361-6439/aab7bf
复制
发表时间：
2018-07-01
影响因子：
2.3
通讯作者：
Zhang, Nan
中科院分区：
文献类型：
--
作者：
Zhang, Haoyang;Fang, Fengzhou;Zhang, Nan
微注射成型已被证明是制造聚合物微流体器件的最有效的批量生产技术之一，在生命科学、环境和分析领域以及农业食品工业中得到了广泛的应用。然而，典型微流控器件的微特征填充复杂且尚未完全了解，从而制约了芯片的发展。本文以具有基本高纵横比微特征的微流控流式细胞仪芯片为典型模型，研究其填充过程。通过短期试验和单因素试验考察了微注射成型过程中注射和填充阶段这些特征的填充过程。系统地监测了颗粒尺寸、包装压力、包装时间和模具温度等工艺参数的影响，并对其进行了表征，并与机器的三维测量结果和螺杆速度、螺杆位置等实际响应进行了关联。提出了一种熔体流动和蠕变联合变形模型来解释过程对复制的复杂影响。提出了一种超冲微注射成型方法，该方法可有效提高高纵横比微特征的复制质量。
Micro injection moulding has been demonstrated as one of the most efficient mass production technologies for manufacturing polymeric microfluidic devices, which have been widely used in life sciences, environmental and analytical fields and agro-food industries. However, the filling of micro features for typical microfluidic devices is complicated and not yet fully understood, which consequently restricts the chip development. In the present work, a microfluidic flow cytometer chip with essential high aspect ratio micro features was used as a typical model to study their filling process. Short-shot experiments and single factor experiments were performed to examine the filling progress of such features during the injection and packing stages of the micro injection moulding process. The influence of process parameters such as shot size, packing pressure, packing time and mould temperature were systematically monitored, characterised and correlated with 3D measurements and real response of the machine such as screw velocity and screw position. A combined melt flow and creep deformation model was proposed to explain the complex influence of process on replication. An approach of over-shot micro injection moulding was proposed and was shown to be effective at improving the replication quality of high aspect ratio micro features.