Successful treatment of bowenoid papulosis in a 9-year-old girl with vertically acquired human immunodeficiency virus.
Successful treatment of bowenoid papulosis in a 9-year-old girl with vertically acquired human immunodeficiency virus.
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成功治疗一名感染垂直获得性人类免疫缺陷病毒的 9 岁女孩的鲍文样丘疹病。
DOI：
10.1542/peds.112.1.e73
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发表时间：
2003
期刊：
影响因子：
8
通讯作者：
Judith V. Williams
中科院分区：
文献类型：
--
作者：
James C. Godfrey;M. Vaughan;Judith V. Williams
一名9岁黑人女孩，患有垂直获得性人类免疫缺陷病毒（HIV），无尖锐湿疣病史，表现为会阴部扩大和扩散的深棕色扁平丘疹4年。有些病变是融合的，从阴蒂延伸到大阴唇，向后延伸到臀部和肛周区域。其中一个病灶的活检显示鲍恩样特征。我们的病人有一个正常的巴氏涂片，但阴道和宫颈活检标本显示人乳头瘤病毒16型。开始每隔一天外用咪喹莫特乳膏治疗，但2个月后几乎没有改善。每4 ~ 8周加用25%鬼臼脂素，1个月内观察到改善。治疗1年后，患者的所有病变完全消退，并且没有进一步的病变表现。我们的病例强调了需要提高对HIV阳性儿童发生鲍恩样丘疹病的认识，以及仅用局部治疗成功治疗我们的患者。
A 9-year-old black girl with vertically acquired human immunodeficiency virus (HIV) and no history of condyloma acuminata presented with a 4-year history of enlarging and spreading dark brown flat papules in the perineum. Some of the lesions were confluent and extended from the clitoris to the labia majora and posteriorly to the buttocks and perianal region. A biopsy of one of the lesions showed bowenoid features. Our patient had a normal Pap smear, but vaginal and cervical biopsy specimens revealed human papillomavirus type 16. Therapy with topical imiquimod cream every other day was started, but little improvement was noted after 2 months. Application of 25% podophyllin every 4 to 8 weeks was added, and improvement was noted within 1 month. After 1 year of treatment, the patient had complete resolution of all lesions, and she has had no further appearance of lesions. Our case emphasizes the need for increased awareness of the potential for development of bowenoid papulosis in HIV-positive children as well as the successful treatment of our patient with topical therapy alone.